Advances in technology have allowed for the sensitive, specific, and simultaneous
quantitative profiling of steroid precursors, bioactive steroids and inactive metabolites …

Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous
system (CNS) with unknown etiology. Several factors were hypothesized to be involved in …

Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease. A
single‐nucleotide polymorphism (SNP), rs6834314, was associated with serum liver …

Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

Nonalcoholic fatty liver disease (NAFLD) is characterized by a massive accumulation of lipid
droplets (LDs). The aim of this study was to determine the function of 17β-hydroxysteroid …

Computational methods are well-established tools in the drug discovery process and can be
employed for a variety of tasks. Common applications include lead identification and scaffold …

Abstract Non-Alcoholic Fatty Liver Disease (NAFLD) refers to the accumulation of lipid laden
vacuoles in hepatocytes, occurring in the context of visceral adiposity, insulin resistance and …

Steroids are important biodynamic agents. Their affinities for various nuclear receptors have
been an interesting feature to utilize them for drug development particularly for receptor …

Huggins and Hodges demonstrated the therapeutic effect of gonadal testosterone
deprivation in the 1940s and therefore firmly established the concept that prostate cancer is …

Hydroxysteroid 17-# x03B2; dehydrogenase 13 (HSD17B13) is a lipid droplet-associated
protein; its gene-encoding variants affect the chronic liver diseases, including nonalcoholic …