The embryo non-invasive pre-implantation diagnosis era: how far are we?

M Del Collado, GM Andrade, NJN Gonçalves… - Animal …, 2023 - SciELO Brasil
Advancements in assisted reproduction (AR) methodologies have allowed significant
improvements in live birth rates of women who otherwise would not be able to conceive …

Reproductive outcomes predicted by phase imaging with computational specificity of spermatozoon ultrastructure

ME Kandel, M Rubessa, YR He… - Proceedings of the …, 2020 - National Acad Sciences
The ability to evaluate sperm at the microscopic level, at high-throughput, would be useful
for assisted reproductive technologies (ARTs), as it can allow specific selection of sperm …

The utility of nuclear magnetic resonance spectroscopy in assisted reproduction

G Asampille, A Cheredath, D Joseph… - Open …, 2020 - royalsocietypublishing.org
Infertility affects approximately 15–20% of individuals of reproductive age worldwide. Over
the last 40 years, assisted reproductive technology (ART) has helped millions of childless …

Lipid profile of bovine grade-1 blastocysts produced either in vivo or in vitro before and after slow freezing process

S Janati Idrissi, D Le Bourhis, A Lefevre, P Emond… - Scientific Reports, 2021 - nature.com
Currently, in vitro embryo production (IVP) is successfully commercially applied in cattle.
However, the high sensitivity of embryos to cryopreservation in comparison to in vivo (IVD) …

Metabolites secreted by bovine embryos in vitro predict pregnancies that the recipient plasma metabolome cannot, and vice versa

E Gomez, N Canela, P Herrero, A Cereto, I Gimeno… - Metabolites, 2021 - mdpi.com
This work describes the use of mass spectrometry-based metabolomics as a non-invasive
approach to accurately predict birth prior to embryo transfer (ET) starting from embryo culture …

Non-invasive identification of sex in cultured bovine embryos by UHPLC-MS/MS metabolomics

I Gimeno, P García-Manrique, S Carrocera… - Metabolomics, 2022 - Springer
Introduction Different gene expression between male and female bovine embryos leads to
metabolic differences. Objective We used UHPLC-MS/MS to identify sex metabolite …

Solution NMR in human embryo culture media as an option for assessment of embryo implantation potential

AM Salmerón, AC Abreu, M VilchesFerrón… - NMR in …, 2021 - Wiley Online Library
NMR offers the potential to holistically screen hundreds of metabolites and has already
proved to be a powerful technique able to provide a global picture of metabolic changes in a …

Nuclear magnetic resonance analysis of female and male pre-hatching embryo metabolites at the embryo-maternal interface

M Muñoz, J Gatien, P Salvetti, D Martín-González… - Metabolomics, 2020 - Springer
Introduction Bovine female and male embryos differentially release metabolites with
signalling effects to culture media. However, it is unknown if the embryo-maternal interface …

The recipient metabolome explains the asymmetric ovarian impact on fetal sex development after embryo transfer in cattle

I Gimeno, P Salvetti, S Carrocera… - Journal of Animal …, 2024 - academic.oup.com
In cattle, lateral asymmetry affects ovarian function and embryonic sex, but the underlying
molecular mechanisms remain unknown. The plasma metabolome of recipients serves to …

Pre-Implantation Bovine Embryo Evaluation—From Optics to Omics and Beyond

RAC Rabel, PV Marchioretto, EA Bangert, K Wilson… - Animals, 2023 - mdpi.com
Simple Summary With conventional breeding practices, even the best dairy/beef cows will
likely produce no more than half-a-dozen calves in their lifetimes; a crime, would you not …