Nuclear bodies (NBs) are biomolecular condensates that participate in various cellular
processes and respond to cellular stimuli in the nucleus. The assembly and function of these …

Although enhancers are central regulators of mammalian gene expression, the mechanisms
underlying enhancer–promoter (EP) interactions remain unclear. Chromosome …

In eukaryotic genomes, transcriptional machinery and nucleosomes compete for binding to
DNA sequences; thus, a crucial aspect of gene regulatory element function is to modulate …

Contacts between enhancers and promoters are thought to relate to their ability to activate
transcription. Investigating factors that contribute to such chromatin interactions is therefore …

Many highly regenerative organisms maintain adult pluripotent stem cells throughout their
life, but how the long-term maintenance of pluripotency is accomplished is unclear. To …

Enhancer RNAs (eRNAs) are non-coding RNAs produced by transcriptional enhancers that
are highly correlated with their activity. Using a capped nascent RNA sequencing (PRO-cap) …

Highlights•Recent work indicates that chromatin compartments can finely segregate
genomic intervals that are 1–2 kb in size.•Evidence both supports and refutes several …

Highlights•Microenvironments are local high concentrations of multiple nuclear factors.•
Microenvironments form due to protein–protein and protein–chromatin interactions.•Local …

The chromosomes in multicellular eukaryotes are organized into a series of topologically
independent loops called TADs. In flies, TADs are formed by physical interactions between …

Highlights•Epigenetic transcriptional regulation allows for maintenance of stable expression
states.•Epigenetic regulation requires DNA methylation, lncRNAs or histone modifications.• …