Two decades of Martini: Better beads, broader scope
The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …
been around for nearly two decades. Originally developed for lipid‐based systems by the …
Nano-based eye drop: Topical and noninvasive therapy for ocular diseases
C Wang, Y Pang - Advanced drug delivery reviews, 2023 - Elsevier
Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering
from their lower bioavailability which highly restricts the treatment efficacy. The introduction …
from their lower bioavailability which highly restricts the treatment efficacy. The introduction …
Converting nanotoxicity data to information using artificial intelligence and simulation
Decades of nanotoxicology research have generated extensive and diverse data sets.
However, data is not equal to information. The question is how to extract critical information …
However, data is not equal to information. The question is how to extract critical information …
Understanding the nano-bio interfaces: Lipid-coatings for inorganic nanoparticles as promising strategy for biomedical applications
A Luchini, G Vitiello - Frontiers in chemistry, 2019 - frontiersin.org
Inorganic nanoparticles (NPs) exhibit relevant physical properties for application in
biomedicine and specifically for both the diagnosis and therapy (ie theranostic) of severe …
biomedicine and specifically for both the diagnosis and therapy (ie theranostic) of severe …
Impact of biogenic and chemogenic selenium nanoparticles on model eukaryotic lipid membranes
Microbial nanotechnology is an expanding research area devoted to producing biogenic
metal and metalloid nanomaterials (NMs) using microorganisms. Often, biogenic NMs are …
metal and metalloid nanomaterials (NMs) using microorganisms. Often, biogenic NMs are …
Ligand Lipophilicity Determines Molecular Mechanisms of Nanoparticle Adsorption to Lipid Bilayers
The interactions of ligand-functionalized nanoparticles with the cell membrane affect cellular
uptake, cytotoxicity, and related behaviors, but relating these interactions to ligand …
uptake, cytotoxicity, and related behaviors, but relating these interactions to ligand …
Unveiling Interactions of Tumor-Targeting Nanoparticles with Lipid Bilayers Using a Titratable Martini Model
Y Cao, J Zhu, J Kou, DP Tieleman… - Journal of Chemical …, 2024 - ACS Publications
pH-responsive nanoparticles are ideal vehicles for drug delivery and are widely used in cell
imaging in targeted therapy of cancer, which usually has a weakly acidic microenvironment …
imaging in targeted therapy of cancer, which usually has a weakly acidic microenvironment …
The role of temperature and lipid charge on intake/uptake of cationic gold nanoparticles into lipid bilayers
Understanding the molecular mechanisms governing nanoparticle–membrane interactions
is of prime importance for drug delivery and biomedical applications. Neutron reflectometry …
is of prime importance for drug delivery and biomedical applications. Neutron reflectometry …
Computational investigation on lipid bilayer disruption induced by amphiphilic Janus nanoparticles: combined effect of Janus balance and charged lipid concentration
Janus nanoparticles (NPs) with charged/hydrophobic compartments have garnered
attention for their potential antimicrobial activity. These NPs have been shown to disrupt lipid …
attention for their potential antimicrobial activity. These NPs have been shown to disrupt lipid …
Energy landscape for the insertion of amphiphilic nanoparticles into lipid membranes: A computational study
RC Van Lehn, A Alexander-Katz - PLoS One, 2019 - journals.plos.org
Amphiphilic, monolayer-protected gold nanoparticles (NPs) have been shown to enter cells
via a non-endocytic, non-disruptive pathway that could be valuable for biomedical …
via a non-endocytic, non-disruptive pathway that could be valuable for biomedical …