The cGAS–STING pathway as a therapeutic target in inflammatory diseases
A Decout, JD Katz, S Venkatraman… - Nature Reviews …, 2021 - nature.com
The cGAS–STING signalling pathway has emerged as a key mediator of inflammation in the
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
settings of infection, cellular stress and tissue damage. Underlying this broad involvement of …
STING agonists as cancer therapeutics
A Amouzegar, M Chelvanambi, JN Filderman… - Cancers, 2021 - mdpi.com
Simple Summary Immunotherapies have revolutionized the field of cancer therapeutics, yet
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …
a substantial subset of patients fail to respond. Recent efforts have focused on identifying …
[HTML][HTML] Biological functions of autophagy genes: a disease perspective
The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …
The STING1 network regulates autophagy and cell death
Cell death and immune response are at the core of life. In past decades, the endoplasmic
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
reticulum (ER) protein STING1 (also known as STING or TMEM173) was found to play a …
[HTML][HTML] TBK1 and IKKε act redundantly to mediate STING-induced NF-κB responses in myeloid cells
KR Balka, C Louis, TL Saunders, AM Smith, DJ Calleja… - Cell reports, 2020 - cell.com
Summary Stimulator of Interferon Genes (STING) is a critical component of host innate
immune defense but can contribute to chronic autoimmune or autoinflammatory disease …
immune defense but can contribute to chronic autoimmune or autoinflammatory disease …
SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool
Stimulator of interferon genes (STING) orchestrates the production of proinflammatory
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
cytokines in response to cytosolic double-stranded DNA; however, the pathophysiological …
STING polymer structure reveals mechanisms for activation, hyperactivation, and inhibition
How the central innate immune protein, STING, is activated by its ligands remains unknown.
Here, using structural biology and biochemistry, we report that the metazoan second …
Here, using structural biology and biochemistry, we report that the metazoan second …
Overview of STING-associated vasculopathy with onset in infancy (SAVI) among 21 patients
ML Frémond, A Hadchouel, L Berteloot, I Melki… - The Journal of Allergy …, 2021 - Elsevier
Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …
ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling
Stimulator of interferon genes (STING) is an intracellular sensor of cyclic di-nucleotides
involved in the innate immune response against pathogen-or self-derived DNA. STING …
involved in the innate immune response against pathogen-or self-derived DNA. STING …
Autophagy in bone homeostasis and the onset of osteoporosis
Autophagy is an evolutionarily conserved intracellular process, in which domestic cellular
components are selectively digested for the recycling of nutrients and energy. This process …
components are selectively digested for the recycling of nutrients and energy. This process …