Comprehensive insights that targeting PIM for cancer therapy: prospects and obstacles
L Chen, W Mao, C Ren, J Li… - Journal of Medicinal …, 2024 - ACS Publications
Proviral integration sitea for Moloney-murine leukemia virus (PIM) kinases are a family of
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …
Technologies of targeting histone deacetylase in drug discovery: Current progress and emerging prospects
J Ru, Y Wang, Z Li, J Wang, C Ren, J Zhang - European Journal of …, 2023 - Elsevier
Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine side chains in
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
AY Park, M Leney-Greene, M Lynberg… - Nature …, 2024 - nature.com
Preserving cells in a functional, non-senescent state is a major goal for extending human
healthspans. Model organisms reveal that longevity and senescence are genetically …
healthspans. Model organisms reveal that longevity and senescence are genetically …
Imidazopyridine-based kinase inhibitors as potential anticancer agents: A review
F Peytam, Z Emamgholipour, A Mousavi, M Moradi… - Bioorganic …, 2023 - Elsevier
Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …
Subtype-selective prenylated isoflavonoids disrupt regulatory drivers of MYCN-amplified cancers
Transcription factors have proven difficult to target with small molecules because they lack
pockets necessary for potent binding. Disruption of protein expression can suppress targets …
pockets necessary for potent binding. Disruption of protein expression can suppress targets …
Emerging opportunities to treat idiopathic pulmonary fibrosis: Design, discovery, and optimizations of small-molecule drugs targeting fibrogenic pathways
Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …
Synthesis and Anticancer Activity of Novel Dual Inhibitors of Human Protein Kinases CK2 and PIM-1
P Wińska, M Wielechowska, M Koronkiewicz… - Pharmaceutics, 2023 - mdpi.com
CK2 and PIM-1 are serine/threonine kinases involved in the regulation of many essential
processes, such as proliferation, differentiation, and apoptosis. Inhibition of CK2 and PIM-1 …
processes, such as proliferation, differentiation, and apoptosis. Inhibition of CK2 and PIM-1 …
Casein kinase 2 (CK2): A possible therapeutic target in acute myeloid leukemia
Ø Bruserud, H Reikvam - Cancers, 2023 - mdpi.com
Simple Summary Acute myeloid leukemia (AML) is an aggressive blood cancer disease that
can only be cured by intensive anticancer treatment, and for several patients, allogeneic …
can only be cured by intensive anticancer treatment, and for several patients, allogeneic …
Strategies of targeting CYP51 for IFIs therapy: Emerging prospects, opportunities and challenges
R Zhang, Y Wang, A Wu, J Wang, J Zhang - European Journal of Medicinal …, 2023 - Elsevier
CYP51, a monooxygenase associated with the sterol synthesis pathway, is responsible for
the catalysis of the 14-methyl hydroxylation reaction of lanosterol precursors. This enzyme is …
the catalysis of the 14-methyl hydroxylation reaction of lanosterol precursors. This enzyme is …
Discovery of a CK2α′-Biased ATP-Competitive Inhibitor from a High-Throughput Screen of an Allosteric-Inhibitor-Like Compound Library
D Mudaliar, RH Mansky, A White… - ACS Chemical …, 2024 - ACS Publications
Protein kinase CK2 is a holoenzyme composed of two regulatory subunits (CK2β) and two
catalytic subunits (CK2α and CK2α′). CK2 controls several cellular processes, including …
catalytic subunits (CK2α and CK2α′). CK2 controls several cellular processes, including …