Proviral integration sitea for Moloney-murine leukemia virus (PIM) kinases are a family of
highly conserved serine/tyrosine kinases consisting of three members, PIM-1, PIM-2, and …

Histone deacetylases (HDACs) catalyze the hydrolysis of acetyl-l-lysine side chains in
histones and non-histones, which are key to epigenetic regulation in humans. Targeting …

Preserving cells in a functional, non-senescent state is a major goal for extending human
healthspans. Model organisms reveal that longevity and senescence are genetically …

Considering the fundamental role of protein kinases in the mechanism of protein
phosphorylation in critical cellular processes, their dysregulation, especially in cancers, has …

Transcription factors have proven difficult to target with small molecules because they lack
pockets necessary for potent binding. Disruption of protein expression can suppress targets …

Idiopathic pulmonary fibrosis (IPF) is the most common fibrotic form of idiopathic diffuse lung
disease. Due to limited treatment options, IPF patients suffer from poor survival. About ten …

CK2 and PIM-1 are serine/threonine kinases involved in the regulation of many essential
processes, such as proliferation, differentiation, and apoptosis. Inhibition of CK2 and PIM-1 …

Simple Summary Acute myeloid leukemia (AML) is an aggressive blood cancer disease that
can only be cured by intensive anticancer treatment, and for several patients, allogeneic …

CYP51, a monooxygenase associated with the sterol synthesis pathway, is responsible for
the catalysis of the 14-methyl hydroxylation reaction of lanosterol precursors. This enzyme is …

Protein kinase CK2 is a holoenzyme composed of two regulatory subunits (CK2β) and two
catalytic subunits (CK2α and CK2α′). CK2 controls several cellular processes, including …