The corticospinal tract (CST) plays a major role in cortical control of spinal cord activity. In
particular, it is the principal motor pathway for voluntary movements. Here, we discuss:(i) the …

Of all brain regions, the 6-layered neocortex has undergone the most dramatic changes in
size and complexity during mammalian brain evolution. These changes, occurring in the …

During cortical development, the identity of major classes of long-distance projection
neurons is established by the expression of molecular determinants, which become …

Generation of distinct cortical projection neuron subtypes during development relies in part
on repression of alternative neuron identities. It was reported that the special AT-rich …

Tcf4 has been linked to autism, schizophrenia, and Pitt-Hopkins Syndrome (PTHS) in
humans, suggesting a role for Tcf4 in brain development and importantly cortical …

SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates
higher-order chromatin configuration. In the adult brain Satb2 is almost exclusively …

Motor, sensory, and integrative activities of the brain are coordinated by a series of midline-
bridging neuronal commissures whose development is tightly regulated. Here we report a …

In mammals, excitatory cortical neurons develop from the proliferative epithelium and
progenitor cells in the ventricular zone and subventricular zone, and migrate radially to the …

Transcription factors establish the tremendous diversity of cell types in the nervous system
by regulating the expression of genes that give a cell its morphological and functional …

A unique combination of transcription factor expression and projection neuron identity
demarcates each layer of the cerebral cortex. During mouse and human cortical …