Reevaluation of treatment guidelines for Old and New World leishmaniasis is urgently
needed on a global basis because treatment failure is an increasing problem. Drug …

Miltefosine is an alkylphosphocholine drug with demonstrated activity against various
parasite species and cancer cells as well as some pathogenic bacteria and fungi. For 10 …

Cutaneous and visceral leishmaniasis are amongst the most devastating infectious diseases
of our time, affecting millions of people worldwide. The treatment of these serious diseases …

In many eukaryotes, phospholipids (PLs) and sphingolipids (SLs) are abundant membrane
components and reservoirs for important signaling molecules. In Leishmania, the …

Epidemics of fatal visceral leishmaniasis caused by the intracellular protozoan Leishmania
are a severe public health problem in tropical and subtropical regions of the world. One …

Abstract Background Pentavalent antimonials (Sb (V)) such as meglumine antimoniate
(Glucantime®) and sodium stibogluconate (Pentostam®) are used as first‐line treatments for …

Leishmaniasis is a serious medical issue in many countries around the World, but it remains
largely neglected in terms of research investment for developing new control and treatment …

Background Miltefosine (MF) is the first oral compound used in the chemotherapy against
leishmaniasis. Since the mechanism of action of this drug and the targets of MF in …

The ATP-binding cassette (ABC) superfamily is one of the largest protein families with
representatives in all kingdoms of life. Members of this superfamily are involved in a wide …

Background ATP-binding cassette (ABC) transporters and P4-ATPases are two large and
seemingly unrelated families of primary active pumps involved in moving phospholipids from …