Increased cardiovascular fitness, V˙ O 2max, is associated with enhanced endurance
capacity and a decreased rate of mortality. High intensity interval training (HIIT) is one of the …

Myofascial pain syndrome is an important health problem. It affects a majority of the general
population, impairs mobility, causes pain, and reduces the overall sense of well‐being …

Calcium (Ca2+) plays a pivotal role in almost all cellular processes and ensures the
functionality of an organism. In skeletal muscle fibers, Ca2+ is critically involved in the …

Muscular dystrophies are a group of diseases characterised by the primary wasting of
skeletal muscle, which compromises patient mobility and in the most severe cases originate …

The identification in a patient of 1 of the 50 variants in the RYR 1 or CACNA 1S genes
reviewed here should lead to a presumption of malignant hyperthermia susceptibility (MHS) …

Our aim is to describe the acute effects of catecholamines/β‐adrenergic agonists on
contraction of non‐fatigued skeletal muscle in animals and humans, and explain the …

Current mechanisms of arrhythmogenesis in catecholaminergic polymorphic ventricular
tachycardia (CPVT) require spontaneous Ca2+ release via cardiac ryanodine receptor …

Direct generation of a homogeneous population of skeletal myoblasts from human
embryonic stem cells (hESCs) and formation of three-dimensional contractile structures for …

Abstract Ryanodine receptor isoform-1 (RyR1) is a major calcium channel in skeletal muscle
important for excitation-contraction coupling. Mutations in the RYR1 gene yield RyR1 protein …

Ryanodine receptors (RyRs) and inositol triphosphate receptors (InsP3Rs) are structurally
related intracellular calcium release channels that participate in multiple primary or …