Background Pain comorbid with depression is frequently encountered in clinical settings
and often leads to significant impaired functioning. Given the complexity of comorbidities, it …

Depression and pain co-exist in almost 80% of patients and are associated with impaired
health-related quality of life, often contributing to high mortality. However, the majority of …

Co-occurrence of chronic pain and clinically significant symptoms of anxiety and/or
depression is regularly noted in the literature. Yet, little is known empirically about …

Introduction. The management of neuropathic pain remains complex, generally because of
the psychiatric comorbidity that is often underdiagnosed. The objectives of our work were to …

Several cross-sectional studies have reported a common comorbidity between depression
and fibromyalgia syndrome (FMS). However, a bidirectional temporal association between …

Objective The aim of this study was to test whether the implementation of an enhanced
recovery after surgery (ERAS) protocol for patients undergoing elective cesarean delivery …

Previous reports have shown that during chronic inflammation, the tryptophan (TRP)-
kynurenine (KYN) pathway plays a pivotal role in the onset of depression. The aim of this …

The prelimbic division (PrL) of the medial prefrontal cortex (mPFC) is a cerebral division that
is putatively implicated in the chronic pain and depression. We investigated the activity of …

Depression is characterized by continuous low mood and loss of interest or pleasure in
enjoyable activities. First-line medications for mood disorders mostly target the …

Chronic stress and chronic pain are two major predisposing factors to trigger depression.
Enhanced excitatory input to the lateral habenula (LHb) has been implicated in the …