Introduction: Beta-lactams are at the cornerstone of therapy in critical care settings, but their
clinical efficacy is challenged by the rise in bacterial resistance. Infections with multi-drug …

Introduction In the time of increasing resistance and paucity of new drug development there
is a growing need for strategies to enhance rational use of antibiotics in German and …

Antimicrobial Stewardship Approaches in the Intensive Care Unit - Infectious Disease Clinics
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Antimicrobial resistance is recognized as a global health crisis. 1 In the United States alone,
more than 2 million patients contract antibiotic-resistant infections that result in 23,000 …

Objectives Alternative dosing strategies for β-lactams–the most common antibiotics used to
treat critically ill patients with respiratory tract infections–have been recommended to …

Objective The purpose of this study is to compare the incidence of acute renal injury (ARI) in
patients on intermittent infusion to extended infusion piperacillin/tazobactam. Methods Data …

Background: Current medical center practice allows for the automatic conversion of all
piperacillin/tazobactam orders from intermittent to extended infusion (EI). Objective: To …

Piperacillin belongs to a semisynthetic group of penicillins called ureidopenicillin that have
been developed to have antipseudomonal broad spectrum activity to be used in the …

Objective The purpose of this study is to evaluate the outcome differences between patients
receiving piperacillin-tazobactam pre-and post-implementation of an extended infusion …

OBJECTIVE: To mathematically assess drug losses due to infusion line residuals and
evaluate methods to compensate for drug loss due to residual volumes in intravenous pump …