Balanced immunity is pivotal for health and homeostasis. CD4+ helper T (Th) cells are
central to the balance between immune tolerance and immune rejection. Th cells adopt …

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system that
causes demyelination, axonal degeneration and astrogliosis, resulting in progressive …

Adoptive immunotherapies based on the transfer of functional immune cells hold great
promise in treating a wide range of malignant diseases, especially cancers, autoimmune …

Endometriosis is defined as the presence of endometrial-like glands and stroma located
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …

Methods Adults (18–42 years) and adolescents (12–17 years) with type 1 diabetes
diagnosed within 150 days were enrolled, with documented evidence of at least one …

Antigen presentation by major histocompatibility complex class II (MHC-II) molecules is
crucial for eliciting an efficient immune response by CD4+ T cells and maintaining self …

Regulatory T cell (Treg) therapy is a promising strategy to treat inflammatory bowel disease
(IBD). Data from animal models has shown that Tregs specific for intestinal antigens are …

Regulatory T cells (Treg) are known to be critical for the maintenance of immune
homeostasis by suppressing the activation of auto-or allo-reactive effector T cells through a …

The aging process is associated with a remodeling of the immune system involving chronic
low-grade inflammation and a gradual decline in the function of the immune system. These …

Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial
impact on patient quality of life and a significant global healthcare burden. Current …