Inflammation, infection and venous thromboembolism
ME Colling, BE Tourdot, Y Kanthi - Circulation research, 2021 - Am Heart Assoc
The association between inflammation, infection, and venous thrombosis has long been
recognized; yet, only in the last decades have we begun to understand the mechanisms …
recognized; yet, only in the last decades have we begun to understand the mechanisms …
Pathophysiological mechanisms of thrombosis in acute and long COVID-19
H Jing, X Wu, M Xiang, L Liu, VA Novakovic… - Frontiers in …, 2022 - frontiersin.org
COVID-19 patients have a high incidence of thrombosis, and thromboembolic complications
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …
are associated with severe COVID-19 and high mortality. COVID-19 disease is associated …
Epigenetic regulator miRNA pattern differences among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 world-wide isolates delineated the mystery behind the epic …
A detailed understanding of the molecular mechanism of SARS-CoV-2 pathogenesis is still
elusive, and there is a need to address its deadly nature and to design effective …
elusive, and there is a need to address its deadly nature and to design effective …
Inflammation and thrombosis in COVID-19 pathophysiology: proteinase-activated and purinergic receptors as drivers and candidate therapeutic targets
K Sriram, PA Insel - Physiological reviews, 2021 - journals.physiology.org
Evolving information has identified disease mechanisms and dysregulation of host biology
that might be targeted therapeutically in coronavirus disease 2019 (COVID-19). Thrombosis …
that might be targeted therapeutically in coronavirus disease 2019 (COVID-19). Thrombosis …
Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
A mast cell–thermoregulatory neuron circuit axis regulates hypothermia in anaphylaxis
IgE-mediated anaphylaxis is an acute life-threatening systemic reaction to allergens,
including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens …
including certain foods and venoms. Anaphylaxis is triggered when blood-borne allergens …
Coagulation and complement: Key innate defense participants in a seamless web
ELG Pryzdial, A Leatherdale, EM Conway - Frontiers in immunology, 2022 - frontiersin.org
In 1969, Dr. Oscar Ratnoff, a pioneer in delineating the mechanisms by which coagulation is
activated and complement is regulated, wrote,“In the study of biological processes, the …
activated and complement is regulated, wrote,“In the study of biological processes, the …
Mechanisms linking hypertriglyceridemia to acute pancreatitis
L Kiss, G Fűr, S Pisipati, P Rajalingamgari… - Acta …, 2023 - Wiley Online Library
Hypertriglyceridemia (HTG) is a metabolic disorder, defined when serum or plasma
triglyceride concentration (seTG) is> 1.7 mM. HTG can be categorized as mild to very severe …
triglyceride concentration (seTG) is> 1.7 mM. HTG can be categorized as mild to very severe …
Beyond thrombosis: the impact of tissue factor signaling in cancer
D Unruh, C Horbinski - Journal of hematology & oncology, 2020 - Springer
Tissue factor (TF) is the primary initiator of the coagulation cascade, though its effects extend
well beyond hemostasis. When TF binds to Factor VII, the resulting TF: FVIIa complex can …
well beyond hemostasis. When TF binds to Factor VII, the resulting TF: FVIIa complex can …
[HTML][HTML] The multifaceted role of plasminogen in inflammation
A fine-tuned activation and deactivation of proteases and their inhibitors are involved in the
execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted …
execution of the inflammatory response. The zymogen/proenzyme plasminogen is converted …