Glutathione transferase classical GSH conjugation activity plays a critical role in cellular
detoxification against xenobiotics and noxious compounds as well as against oxidative …

From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …

Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …

Multifunctional enzymes glutathione transferases (GSTs) are involved in the development of
chemoresistance, thus representing a promising target for a novel approach in cancer …

Metal complexes are increasingly being used to inhibit enzymes. The reasons for this
increased interest arise from the special features that metal complexes offer, eg the facile …

The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug
resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the …

Gold (III) complexes have emerged as a versatile and effective class of metal‐based
anticancer agents. The development of various types of ligands capable of stabilizing the …

Proteasomes are attractive emerging targets for anti-cancer therapies. Auranofin (Aur), a
gold-containing compound clinically used to treat rheumatic arthritis, was recently approved …

Anticancer drugs that target cellular antioxidant systems have recently attracted much
attention. Auranofin (AF) is currently evaluated in several clinical trials as an anticancer …

Metal-based compounds form a promising class of therapeutic agents, whose mechanisms
of action still need to be elucidated, and that are in general prone to undergo extensive …