[HTML][HTML] Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases
Glutathione transferase classical GSH conjugation activity plays a critical role in cellular
detoxification against xenobiotics and noxious compounds as well as against oxidative …
detoxification against xenobiotics and noxious compounds as well as against oxidative …
A golden future in medicinal inorganic chemistry: the promise of anticancer gold organometallic compounds
B Bertrand, A Casini - Dalton Transactions, 2014 - pubs.rsc.org
From wedding rings on fingers to stained glass windows, by way of Olympic medals, gold
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …
has been highly prized for millennia. Nowadays, organometallic gold compounds occupy an …
New insights in Au-NHCs complexes as anticancer agents
Within the research field of antitumor metal-based agents alternative to platinum drugs, gold
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …
(I/III) coordination complexes have always been in the forefront due mainly to the familiarity …
Glutathione transferases: potential targets to overcome chemoresistance in solid tumors
M Pljesa-Ercegovac, A Savic-Radojevic… - International journal of …, 2018 - mdpi.com
Multifunctional enzymes glutathione transferases (GSTs) are involved in the development of
chemoresistance, thus representing a promising target for a novel approach in cancer …
chemoresistance, thus representing a promising target for a novel approach in cancer …
[HTML][HTML] Enzyme inhibition by metal complexes: concepts, strategies and applications
KJ Kilpin, PJ Dyson - Chemical Science, 2013 - pubs.rsc.org
Metal complexes are increasingly being used to inhibit enzymes. The reasons for this
increased interest arise from the special features that metal complexes offer, eg the facile …
increased interest arise from the special features that metal complexes offer, eg the facile …
[HTML][HTML] Monocarbonyl curcumin analogues as potent inhibitors against human glutathione transferase p1-1
The isoenzyme of human glutathione transferase P1-1 (hGSTP1-1) is involved in multi-drug
resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the …
resistance (MDR) mechanisms in numerous cancer cell lines. In the present study, the …
Gold (III) complexes for antitumor applications: An overview
B Bertrand, MRM Williams… - Chemistry–A European …, 2018 - Wiley Online Library
Gold (III) complexes have emerged as a versatile and effective class of metal‐based
anticancer agents. The development of various types of ligands capable of stabilizing the …
anticancer agents. The development of various types of ligands capable of stabilizing the …
[HTML][HTML] Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth
N Liu, X Li, H Huang, C Zhao, S Liao, C Yang, S Liu… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Proteasomes are attractive emerging targets for anti-cancer therapies. Auranofin (Aur), a
gold-containing compound clinically used to treat rheumatic arthritis, was recently approved …
gold-containing compound clinically used to treat rheumatic arthritis, was recently approved …
[HTML][HTML] Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than …
P Sabatier, CM Beusch, R Gencheva, Q Cheng… - Redox Biology, 2021 - Elsevier
Anticancer drugs that target cellular antioxidant systems have recently attracted much
attention. Auranofin (AF) is currently evaluated in several clinical trials as an anticancer …
attention. Auranofin (AF) is currently evaluated in several clinical trials as an anticancer …
Mass spectrometry as a powerful tool to study therapeutic metallodrugs speciation mechanisms: Current frontiers and perspectives
M Wenzel, A Casini - Coordination Chemistry Reviews, 2017 - Elsevier
Metal-based compounds form a promising class of therapeutic agents, whose mechanisms
of action still need to be elucidated, and that are in general prone to undergo extensive …
of action still need to be elucidated, and that are in general prone to undergo extensive …