[HTML][HTML] Immune targets for therapeutic development in depression: towards precision medicine

WC Drevets, GM Wittenberg, ET Bullmore… - Nature reviews Drug …, 2022 - nature.com
Over the past two decades, compelling evidence has emerged indicating that immune
mechanisms can contribute to the pathogenesis of major depressive disorder (MDD) and …

[HTML][HTML] Endoplasmic reticulum stress-associated neuronal death and innate immune response in neurological diseases

M Shi, Y Chai, J Zhang, X Chen - Frontiers in immunology, 2022 - frontiersin.org
Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment‐Responsive BAPTA‐AM/BAC Co …

J Yan, Y Wang, J Zhang, X Liu, L Yu, Z He - Small, 2023 - Wiley Online Library
Calcium overload and ROS overproduction, two major triggers of acute kidney injury (AKI),
are self‐amplifying and mutually reinforcing, forming a complicated cascading feedback …

Polystyrene nanoplastics-induced lung apoptosis and ferroptosis via ROS-dependent endoplasmic reticulum stress

Q Wu, C Liu, D Liu, Y Wang, H Qi, X Liu… - Science of The Total …, 2024 - Elsevier
It has been shown that exposure to nanoplastics (MNPs) through inhalation can induce
pulmonary toxicity, but the toxicological mechanism of MNPs on the respiratory system …

Mammalian integrated stress responses in stressed organelles and their functions

H Lu, N Koju, R Sheng - Acta Pharmacologica Sinica, 2024 - nature.com
The integrated stress response (ISR) triggered in response to various cellular stress enables
mammalian cells to effectively cope with diverse stressful conditions while maintaining their …

[HTML][HTML] C9-ALS-associated proline-arginine dipeptide repeat protein induces activation of NLRP3 inflammasome of HMC3 microglia cells by binding of complement …

RH Fu, CW Tsai, SC Chiu, SP Liu, YT Chiang, YH Kuo… - Cells, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease in which motor neurons gradually
degenerate. The mutation of the C9orf72 gene is the main genetic cause of ALS (C9-ALS) …

Intervention effects of sulfate glycosaminoglycan from swim bladder against arsenic-induced damage in IEC-6 cells

J Ou, Z Wang, H Huang, J Chen, X Liu, X Jia… - International Journal of …, 2023 - Elsevier
In this study, a purified macromolecular sulfate glycosaminoglycan whose structural
characterization is similar to chondroitin sulfate from the swim bladder of Aristichthys nobilis …

The therapeutic effects of berberine against different diseases: A review on the involvement of the endoplasmic reticulum stress

F Yarmohammadi, AW Hayes… - Phytotherapy …, 2022 - Wiley Online Library
Various factors interfere with the endoplasmic reticulum (ER) function, which is involved in
protein folding and calcium homeostasis. ER dysfunction referred to as ER stress triggers …

[HTML][HTML] Melissa officinalis extract suppresses endoplasmic reticulum stress-induced apoptosis in the brain of hypothyroidism-induced rats exposed to γ-radiation

OAR Abo-Zaid, FSM Moawed, EFS Taha… - Cell Stress and …, 2023 - Elsevier
The purpose of this study was to demonstrate the neuroprotective effect of Melissa officinalis
extract (MEE) against brain damage associated with hypothyroidism induced by …

Triphenyl phosphate (TPP) promotes hepatocyte toxicity via induction of endoplasmic reticulum stress and inhibition of autophagy flux

M Li, G Liu, LX Yuan, J Yang, J Liu, Z Li, C Yang… - Science of The Total …, 2022 - Elsevier
Triphenyl phosphate (TPP), a commonly used organophosphate flame retardant, is
frequently found in environmental and biota samples, indicating widespread human …