Apoptosis or programmed cell death is natural way of removing aged cells from the body.
Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks …

Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …

Nuclear pore complexes (NPCs) create large conduits for cargo transport between the
nucleus and cytoplasm across the nuclear envelope (NE),–. These multi-megadalton …

Proximity-dependent biotin identification (BioID) is a method for identifying protein
associations that occur in vivo. By fusing a promiscuous biotin ligase to a protein of interest …

The nuclear lamina is an important structural determinant for the nuclear envelope as a
whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

At the turn of the twenty-first century, fundamental changes took place in the understanding
of the structure and function of proteins and then in the appreciation of the intracellular …

Calcium (Ca2+) is a universal regulator of various cellular functions. In cardiomyocytes,
Ca2+ is the central element of excitation–contraction coupling, but also impacts diverse …

Nuclear targeting of therapeutics provides a strategy for enhancing efficacy of molecules
active in the nucleus and minimizing off-target effects.'Active'nuclear-directed transport and …

It is clear now that eukaryotic cells contain numerous membrane-less organelles, many of
which are formed in response to changes in the cellular environment. Being typically liquid …