Radial stem astrocytes (aka neural stem cells): identity, development, physio‐pathology, and therapeutic potential

CY Yeh, KY Wu, GJ Huang, A Verkhratsky - Acta Physiologica, 2023 - Wiley Online Library
Adult neurogenesis is a striking example of neuroplasticity, which enables adaptive network
remodelling in response to all forms of environmental stimulation in physiological and …

Application of biomarker-derived fluorescent probes for the detection of Alzheimer's disease

H Ding, Z Li, K Luo, Q Gong, X Tian - TrAC Trends in Analytical Chemistry, 2023 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the
accumulation of beta-amyloid (Aβ) protein and neurofibrillary tangles in the brain, resulting …

Microbiota from Alzheimer's patients induce deficits in cognition and hippocampal neurogenesis

S Grabrucker, M Marizzoni, E Silajdžić, N Lopizzo… - Brain, 2023 - academic.oup.com
Alzheimer's disease is a complex neurodegenerative disorder leading to a decline in
cognitive function and mental health. Recent research has positioned the gut microbiota as …

Nerve growth factor receptor (Ngfr) induces neurogenic plasticity by suppressing reactive astroglial Lcn2/Slc22a17 signaling in Alzheimer's disease

T Siddiqui, MI Cosacak, S Popova, P Bhattarai… - npj Regenerative …, 2023 - nature.com
Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …

[PDF][PDF] Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction

H Li, L Xu, W Jiang, X Qiu, H Xu, F Zhu, Y Hu, S Liang… - Cell Reports, 2023 - cell.com
Cognitive impairment has been associated with an age-related decline in adult hippocampal
neurogenesis (AHN). The molecular basis of declining neurogenesis in the aging …

Dapagliflozin Ameliorates Cognitive Impairment in Aluminum-Chloride-Induced Alzheimer's Disease via Modulation of AMPK/mTOR, Oxidative Stress and Glucose …

WA Samman, SM Selim, HM El Fayoumi, NM El-Sayed… - Pharmaceuticals, 2023 - mdpi.com
Alzheimer's disease (AD) is a progressive neurological illness characterized by memory loss
and cognitive deterioration. Dapagliflozin was suggested to attenuate the memory …

Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice

P Bielefeld, A Martirosyan, S Martín-Suárez… - Nature …, 2024 - nature.com
Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The
changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult …

It takes two to untangle: Combined stimulation of adult neurogenesis reverts AD symptoms

R Gabarró-Solanas, N Urbán - Cell Stem Cell, 2023 - cell.com
Alzheimer's disease (AD) is associated with reduced adult hippocampal neurogenesis and
impaired hippocampal-dependent behaviors. Li et al. 1 report that stimulating adult …

Ageing, cognitive decline, and effects of physical exercise: complexities, and considerations from animal models

GM Caruso, S Nicolas, PJ Lucassen, JD Mul… - Brain …, 2024 - content.iospress.com
In our ageing global population, the cognitive decline associated with dementia and
neurodegenerative diseases represents a major healthcare problem. To date, there are no …

[HTML][HTML] Memory Circuits in Dementia: The Engram, Hippocampal Neurogenesis and Alzheimer's disease

O Lazarov, M Gupta, P Kumar, Z Morrissey… - Progress in …, 2024 - Elsevier
Here, we provide an in-depth consideration of our current understanding of engrams,
spanning from molecular to network levels, and hippocampal neurogenesis, in health and …