The Mechanisms of Disease Caused by Acinetobacter baumannii

FC Morris, C Dexter, X Kostoulias, MI Uddin… - Frontiers in …, 2019 - frontiersin.org
Acinetobacter baumannii is a Gram negative opportunistic pathogen that has demonstrated
a significant insurgence in the prevalence of infections over recent decades. With only a …

[HTML][HTML] Acinetobacter spp. as nosocomial pathogens: Epidemiology and resistance features

SB Almasaudi - Saudi journal of biological sciences, 2018 - Elsevier
The genus Acinetobacter is a major cause of nosocomial infections; it is increasingly being
associated with various epidemics and has become a widespread concern in a variety of …

Mobile genetic elements in Acinetobacter antibiotic‐resistance acquisition and dissemination

HR Noel, JR Petrey, LD Palmer - … of the New York Academy of …, 2022 - Wiley Online Library
Pathogenic Acinetobacter species, most notably Acinetobacter baumannii, are a significant
cause of healthcare‐associated infections worldwide. Acinetobacter infections are of …

Acinetobacter baumannii can use multiple siderophores for iron acquisition, but only acinetobactin is required for virulence

JR Sheldon, EP Skaar - PLoS pathogens, 2020 - journals.plos.org
Acinetobacter baumannii is an emerging pathogen that poses a global health threat due to a
lack of therapeutic options for treating drug-resistant strains. In addition to acquiring …

Clinical and pathophysiological overview of Acinetobacter infections: a century of challenges

D Wong, TB Nielsen, RA Bonomo… - Clinical microbiology …, 2017 - Am Soc Microbiol
Acinetobacter is a complex genus, and historically, there has been confusion about the
existence of multiple species. The species commonly cause nosocomial infections …

Acinetobacter baumannii

C Whiteway, A Breine, C Philippe… - Trends in microbiology, 2022 - cell.com
Acinetobacter baumannii is a ubiquitous, Gram-negative, nonflagellated coccobacillus
bacterium commonly isolated from the environment. In human medicine, this opportunistic …

Rapid microevolution of biofilm cells in response to antibiotics

A Penesyan, SS Nagy, S Kjelleberg… - NPJ biofilms and …, 2019 - nature.com
Infections caused by Acinetobacter baumannii are increasingly antibiotic resistant,
generating a significant public health problem. Like many bacteria, A. baumannii adopts a …

Systematic analyses identify modes of action of ten clinically relevant biocides and antibiotic antagonism in Acinetobacter baumannii

L Li, FL Short, KA Hassan, V Naidu, A Pokhrel… - Nature …, 2023 - nature.com
Concerns exist that widespread use of antiseptic or disinfectant biocides could contribute to
the emergence and spread of multidrug-resistant bacteria. To investigate this, we performed …

Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope

E Geisinger, NJ Mortman, Y Dai, M Cokol… - Nature …, 2020 - nature.com
A unique, protective cell envelope contributes to the broad drug resistance of the
nosocomial pathogen Acinetobacter baumannii. Here we use transposon insertion …

Essential gene knockdowns reveal genetic vulnerabilities and antibiotic sensitivities in Acinetobacter baumannii

RD Ward, JS Tran, AB Banta, EE Bacon, WE Rose… - Mbio, 2024 - Am Soc Microbiol
The emergence of multidrug-resistant Gram-negative bacteria underscores the need to
define genetic vulnerabilities that can be therapeutically exploited. The Gram-negative …