Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of diabetes
worldwide. The number affected is increasing rapidly with alarming trends in children and …

Diabetic kidney disease (DKD) is one of the fastest growing causes of chronic kidney
disease and associated morbidity and mortality. Preclinical research has demonstrated the …

Among 20 leading global risk factors for years of life lost in 2040, reference forecasts point to
three metabolic risks—high blood pressure, high BMI, and high fasting plasma glucose—as …

Background Heterogeneity in type 2 diabetes presentation and progression suggests that
precision medicine interventions could improve clinical outcomes. We undertook a …

Diabetes is a highly heterogeneous condition; yet, it is diagnosed by measuring a single
blood-borne metabolite, glucose, irrespective of aetiology. Although pragmatically helpful …

Aims/hypothesis Type 2 diabetes is highly polygenic and influenced by multiple biological
pathways. Rapid expansion in the number of type 2 diabetes loci can be leveraged to …

Diabetes is a chronic metabolic disease, and its therapeutic goals focus on the effective
management of blood glucose and various complications. Drug combination therapy has …

Climate change will be a major challenge for the world's health systems in the coming
decades. Elevated temperatures and increasing frequencies of heat waves, wildfires, heavy …

Background Heterogeneity in type 2 diabetes can be represented by a tree-like graph
structure by use of reversed graph-embedded dimensionality reduction. We aimed to …

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent
hyperglycemia due to insulin resistance or failure to produce insulin. Patients with DM …