The metabolism of the non-essential amino acid L-proline is emerging as a key pathway in
the metabolic rewiring that sustains cancer cells proliferation, survival and metastatic …

Cancer poses a significant global health challenge, with predictions of increasing
prevalence in the coming years due to limited prevention, late diagnosis, and inadequate …

Proline, glutamine, asparagine, and arginine are conditionally non-essential amino acids
that can be produced in our body. However, they are essential for the growth of highly …

Emerging evidence suggests that proline metabolism is important for regulating the survival
and death of different types of cancer cells. Proline dehydrogenase (PRODH), an enzyme …

Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most frequently prescribed
drug classes with wide therapeutic applications over the centuries. Starting from the use of …

Viruses lack essential living system, so they must hijack host cell metabolism for its survival
and reproduction. Interestingly, the metabolic reprogramming induced by oncovirus is critical …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered to be therapeutics in cancer
prevention because of their inhibitory effect on cyclooxygenases (COX), which are frequently …

Simple Summary Studies of various types of cancers have found proline metabolism to be a
key player in tumor development, involved in basic metabolic pathways, regulating cell …

Recent studies on the regulatory role of amino acids in cell metabolism have focused on the
functional significance of proline degradation. The process is catalysed by proline …

L-proline catabolism is emerging as a key pathway that is critical to cellular metabolism,
growth, survival, and death. Proline dehydrogenase (PRODH) enzyme, which catalyzes the …