Although cancer was originally considered a disease driven only by genetic mutations, it has
now been proven that it is also an epigenetic disease driven by DNA hypermethylation …

Alzheimer's disease (AD) is a multifactorial, age-related neurological disease characterized
by complex pathophysiological dynamics taking place at multiple biological levels, including …

Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3′
end of RNA polymerase II transcripts from over 60% of human genes. APA is derived from …

Background More than 170 post-transcriptional RNA modifications regulate the localization,
processing and function of cellular RNAs, and aberrant RNA modifications have been linked …

Understanding cellular coordination remains a challenge despite knowledge of individual
pathways. The RNA exosome, targeting a wide range of RNA substrates, is often …

Viruses promote infection by hijacking the ubiquitin machinery of the host to counteract or
redirect cellular processes. Adenovirus encodes two early proteins, E1B55K and E4orf6, that …

Balancing mRNA nuclear export kinetics with its nuclear decay is critical for mRNA
homeostasis control. How this equilibrium is aberrantly disrupted in esophageal cancer to …

The nuclear pore complex (NPC) serves as a central gate for mRNAs to transit from the
nucleus to the cytoplasm. The ability for mRNAs to get exported is linked to various upstream …

Transcription establishes the universal first step of gene expression where RNA is produced
by a DNA-dependent RNA polymerase. The most versatile of eukaryotic RNA polymerases …

The passage of mRNAs through the nuclear pores into the cytoplasm is essential in all
eukaryotes. For regulation, mRNA export is tightly connected to the full machinery of nuclear …