Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease. PCOS
patients are characterized by hyperandrogenemia, anovulation, and metabolic dysfunction …

Obesity and type 2 diabetes account for a considerable proportion of the global burden of
age-related metabolic diseases. In age-related metabolic diseases, tissue crosstalk and …

Back and neck pain are significant healthcare burdens that are commonly associated with
pathologies of the intervertebral disc (IVD). The poor understanding of the cellular …

Spexin (SPX, NPQ), a novel endogenous neuropeptide, was firstly identified by
bioinformatics. Spexin gene and protein widely distributed in the central nervous system and …

It is known that a strong association exists between a suboptimal lifestyle (physical inactivity
and sedentary behavior and/or high calorie diet) and increased propensity of developing …

Consumption of a high calorie diet with irregular eating and sedentary behavior habits is
typical of the current suboptimal lifestyle, contributing to the development of metabolic …

Aim The present study aimed to investigate the effect of the intracerebroventricular (icv)
administration of spexin on the hypothalamus-pituitary-thyroid (HPT) axis (TRH, TSH, T4 and …

Skeletal muscle is a principal tissue involved in energy expenditure and glucose
metabolism. Although the results of our and other studies show that spexin could decrease …

Background Type 2 diabetes mellitus is a complex metabolic disorder associated with
obesity, glucose intolerance and insulin resistance. Activation of GALR2 has been proposed …

The present study was to explore whether alarin could alleviate heart failure (HF) and
attenuate cardia fibrosis via inhibiting oxidative stress. The fibrosis of cardiac fibroblasts …