Methods and applications for single-cell and spatial multi-omics
K Vandereyken, A Sifrim, B Thienpont… - Nature Reviews Genetics, 2023 - nature.com
The joint analysis of the genome, epigenome, transcriptome, proteome and/or metabolome
from single cells is transforming our understanding of cell biology in health and disease. In …
from single cells is transforming our understanding of cell biology in health and disease. In …
The emerging landscape of spatial profiling technologies
Improved scale, multiplexing and resolution are establishing spatial nucleic acid and protein
profiling methods as a major pillar for cellular atlas building of complex samples, from …
profiling methods as a major pillar for cellular atlas building of complex samples, from …
Spatial profiling technologies illuminate the tumor microenvironment
O Elhanani, R Ben-Uri, L Keren - Cancer cell, 2023 - cell.com
The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …
components that together drive tumor growth, invasion, metastasis, and response to …
SODB facilitates comprehensive exploration of spatial omics data
Spatial omics technologies generate wealthy but highly complex datasets. Here we present
Spatial Omics DataBase (SODB), a web-based platform providing both rich data resources …
Spatial Omics DataBase (SODB), a web-based platform providing both rich data resources …
Wilds: A benchmark of in-the-wild distribution shifts
Distribution shifts—where the training distribution differs from the test distribution—can
substantially degrade the accuracy of machine learning (ML) systems deployed in the wild …
substantially degrade the accuracy of machine learning (ML) systems deployed in the wild …
Analyzing cell-type-specific dynamics of metabolism in kidney repair
A common drawback of metabolic analyses of complex biological samples is the inability to
consider cell-to-cell heterogeneity in the context of an organ or tissue. To overcome this …
consider cell-to-cell heterogeneity in the context of an organ or tissue. To overcome this …
Advances in mass spectrometry imaging for spatial cancer metabolomics
X Ma, FM Fernández - Mass spectrometry reviews, 2024 - Wiley Online Library
Mass spectrometry (MS) has become a central technique in cancer research. The ability to
analyze various types of biomolecules in complex biological matrices makes it well suited for …
analyze various types of biomolecules in complex biological matrices makes it well suited for …
Plant–microbe interactions in the rhizosphere via a circular metabolic economy
Chemical exchange often serves as the first step in plant–microbe interactions and
exchanges of various signals, nutrients, and metabolites continue throughout the interaction …
exchanges of various signals, nutrients, and metabolites continue throughout the interaction …
[HTML][HTML] Single-cell metabolomics: where are we and where are we going?
I Lanekoff, VV Sharma, C Marques - Current opinion in biotechnology, 2022 - Elsevier
Single-cell metabolomics with mass spectrometry enables a large variety of metabolites to
be simultaneously detected from individual cells, without any preselection or labelling, to …
be simultaneously detected from individual cells, without any preselection or labelling, to …
High spatial resolution mass spectrometry imaging for spatial metabolomics: Advances, challenges, and future perspectives
S Ma, Y Leng, X Li, Y Meng, Z Yin, W Hang - TrAC Trends in Analytical …, 2023 - Elsevier
Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …