The adenosine triphosphate binding cassette (ABC) transporters are one of the largest
transmembrane gene families in humans. The ABC transporters are present in a number of …

Sonneveld P (University Hospital Rotterdam–Dijkzigt, The Netherlands). Multidrug
resistance in haematological malignancies (Internal Medicine in the 21st Century). J Intern …

We studied 53 patients with B-cell chronic lymphocytic leukemia (B-CLL) and found
mutations of the p53 gene in 15%. Patients with p53 gene mutations were found to have an …

The mechanism of action of chemotherapeutic drugs and their ability to induce multidrug
resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein …

Identifying new chemotherapeutic agents and characterizing mechanisms of resistance may
improve cancer treatment. The Anticancer Drug Screen of the National Cancer Institute uses …

Resistance to chemotherapy is a major factor limiting successful treatment of acute myeloid
leukemia (AML); one of the best characterized drug resistance mechanisms is extrusion of …

A retrospective analysis was performed on 235 elderly acute myelogenous leukaemia (AML)
patients aged 60 years or more, consecutively admitted to a single haematological …

The expression of the MDR-1-encoded P-170 glycoprotein (P-170) associated with clinical
multidrug resistance (MDR) was investigated in 52 consecutive patients with untreated acute …

Overexpression of P‐glycoprotein (P‐gp) contributes to the multidrug resistance (MDR)
phenotype found in many cancer cells. P‐gp has been identified as a promising molecular …

Cytofluorimetric detection of the multidrug resistance (MDR)-associated membrane protein
(P-170) was performed at the time of diagnosis in 158 patients with acute myeloid leukemia …