The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic Chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Informing deep neural networks by multiscale principles of neuromodulatory systems

J Mei, E Muller, S Ramaswamy - Trends in Neurosciences, 2022 - cell.com
Our brains have evolved the ability to configure and adapt their processing states to match
the unique challenges of acting and learning in diverse environments and behavioral …

Mechanisms and treatment strategies of organophosphate pesticide induced neurotoxicity in humans: A critical appraisal

SY Ganie, D Javaid, YA Hajam, MS Reshi - Toxicology, 2022 - Elsevier
Organophosphates (OPs) are commonly used pesticides worldwide. Humans are exposed
to OPs via different routes viz., the respiratory tract, gastrointestinal tract, and dermal …

Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals

G Bjørklund, H Antonyak, A Polishchuk… - Archives of …, 2022 - Springer
Methylmercury (MeHg) is a global environmental pollutant with neurotoxic effects. Exposure
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …

Are kynurenines accomplices or principal villains in dementia? Maintenance of kynurenine metabolism

M Tanaka, Z Bohár, L Vécsei - Molecules, 2020 - mdpi.com
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …

G-protein-coupled receptors in CNS: a potential therapeutic target for intervention in neurodegenerative disorders and associated cognitive deficits

S Azam, ME Haque, M Jakaria, SH Jo, IS Kim, DK Choi - Cells, 2020 - mdpi.com
Neurodegenerative diseases are a large group of neurological disorders with diverse
etiological and pathological phenomena. However, current therapeutics rely mostly on …

Environmental exposures and sleep outcomes: a review of evidence, potential mechanisms, and implications

J Liu, L Ghastine, P Um, E Rovit, T Wu - Environmental research, 2021 - Elsevier
Environmental exposures and poor sleep outcomes are known to have consequential
effects on human health. This integrative review first seeks to present and synthesize …

Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases

V Borroni, FJ Barrantes - Membranes, 2021 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
involved in the modulation of essential brain functions such as memory, learning, and …

Local thyroid hormone action in brain development

A Alcaide Martin, S Mayerl - International Journal of Molecular Sciences, 2023 - mdpi.com
Proper brain development essentially depends on the timed availability of sufficient amounts
of thyroid hormone (TH). This, in turn, necessitates a tightly regulated expression of TH …