The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators
LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic Chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …
Basal forebrain cholinergic signalling: development, connectivity and roles in cognition
MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …
mapped the activity and functional connectivity of cholinergic neurons have shown that the …
Informing deep neural networks by multiscale principles of neuromodulatory systems
Our brains have evolved the ability to configure and adapt their processing states to match
the unique challenges of acting and learning in diverse environments and behavioral …
the unique challenges of acting and learning in diverse environments and behavioral …
Mechanisms and treatment strategies of organophosphate pesticide induced neurotoxicity in humans: A critical appraisal
Organophosphates (OPs) are commonly used pesticides worldwide. Humans are exposed
to OPs via different routes viz., the respiratory tract, gastrointestinal tract, and dermal …
to OPs via different routes viz., the respiratory tract, gastrointestinal tract, and dermal …
Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals
G Bjørklund, H Antonyak, A Polishchuk… - Archives of …, 2022 - Springer
Methylmercury (MeHg) is a global environmental pollutant with neurotoxic effects. Exposure
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …
to MeHg via consumption of seafood and fish can severely impact fetal neurobehavioral …
Are kynurenines accomplices or principal villains in dementia? Maintenance of kynurenine metabolism
Worldwide, 50 million people suffer from dementia, a group of symptoms affecting cognitive
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …
and social functions, progressing severely enough to interfere with daily life. Alzheimer's …
G-protein-coupled receptors in CNS: a potential therapeutic target for intervention in neurodegenerative disorders and associated cognitive deficits
Neurodegenerative diseases are a large group of neurological disorders with diverse
etiological and pathological phenomena. However, current therapeutics rely mostly on …
etiological and pathological phenomena. However, current therapeutics rely mostly on …
Environmental exposures and sleep outcomes: a review of evidence, potential mechanisms, and implications
Environmental exposures and poor sleep outcomes are known to have consequential
effects on human health. This integrative review first seeks to present and synthesize …
effects on human health. This integrative review first seeks to present and synthesize …
Homomeric and heteromeric α7 nicotinic acetylcholine receptors in health and some central nervous system diseases
V Borroni, FJ Barrantes - Membranes, 2021 - mdpi.com
Nicotinic acetylcholine receptors (nAChRs) are pentameric ligand-gated ion channels
involved in the modulation of essential brain functions such as memory, learning, and …
involved in the modulation of essential brain functions such as memory, learning, and …
Local thyroid hormone action in brain development
A Alcaide Martin, S Mayerl - International Journal of Molecular Sciences, 2023 - mdpi.com
Proper brain development essentially depends on the timed availability of sufficient amounts
of thyroid hormone (TH). This, in turn, necessitates a tightly regulated expression of TH …
of thyroid hormone (TH). This, in turn, necessitates a tightly regulated expression of TH …