According to recent data, several mechanisms of viral invasion of the central nervous system
(CNS) have been proposed, one of which is both direct penetration of the virus through …

The vast majority of cortical synapses are found in the neuropil which is implicated in
multiple and diverse functions underlying brain computation. Unraveling the organizing …

Predicting the response of the cortical microcircuit to perturbations is a prerequisite to
determine the mechanisms that mediate its response to stimulus; yet, an encompassing …

The cholinergic system plays a fundamental role in learning and memory. Pharmacological
activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces …

We used the immunotoxin 192 immunoglobulin G-saporin to produce a selective cholinergic
lesion in the nucleus basalis of Meynert (NBM) of rats and investigated whether the NBM …

Plectranthus esculentus is a plant used to relieve pain and digestive disorders. 4-
Vinylcyclohexene 1, 2-monoepoxide (VCM) is a toxic metabolite of 4-vinylcyclohexene. The …

The neuromodulator acetylcholine (ACh) plays an important role in arousal, attention,
vigilance, learning and memory. ACh is released during different behavioural states and …

The basal ganglia are a collection of subcortical nuclei involved in movement and action
selection. The striatum is the main input nucleus with extensive projections from the cortex …

Cholinergic signaling is involved with a variety of brain functions including learning and
memory, attention, and behavioral state modulation. The spatiotemporal characteristics of …

A mathematical model of initiation mechanism for focal limbic seizures is proposed. The
epileptic focus is assumed to be a relatively small network (epileptic subcircuit) of neurons …