Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Laboratory mice have provided invaluable insight into mammalian immune systems. Yet the
immune phenotypes of mice bred and maintained in conventional laboratory conditions …

Adipose tissue is usually classified on the basis of its function as white, brown or beige
(brite). It is an important regulator of systemic metabolism, as shown by the fact that …

Human and mouse thermal physiology differ due to dissimilar body sizes. Unexpectedly, in
mice we found no ambient temperature zone where both metabolic rate and body …

Aim: Exercise training elicits diverse effects on brown (BAT) and white adipose tissue (WAT)
physiology in rodents housed below their thermoneutral zone (ie, 28–32° C). In these …

Negative regulation of exocytosis from secretory cells is accomplished through inhibitory
signals from Gi/o GPCRs by Gβγ subunit inhibition of 2 mechanisms: decreased calcium …

Building upon the success of the Handbook of Laboratory Animal Science and completing
Volumes I and II of the Second Edition, Handbook of Laboratory Animal Science, Second …

Key points Mice are commonly housed at room temperatures below their thermoneutral
zone meaning they are exposed to chronic thermal stress. Endurance exercise induces …

Brown adipocyte in brown adipose tissue (BAT) specializes in expending energy through
non-shivering thermogenesis, a process that produces heat either by uncoupling protein 1 …

New Findings What is the topic of this review? It has been suggested that human brown
adipose tissue (BAT) is more similar to the brite/beige adipose tissue of mice than to …