Biomaterials and advanced technologies for hemostatic management of bleeding

DSA Hickman, CL Pawlowski, UDS Sekhon… - Advanced …, 2018 - Wiley Online Library
Bleeding complications arising from trauma, surgery, and as congenital, disease‐
associated, or drug‐induced blood disorders can cause significant morbidities and …

Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies

H Jiang, X Zhang, X Chen, P Aramsangtienchai… - Chemical …, 2018 - ACS Publications
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

N Scott‐Hewitt, F Perrucci, R Morini, M Erreni… - The EMBO …, 2020 - embopress.org
Neuronal circuit assembly requires the fine balance between synapse formation and
elimination. Microglia, through the elimination of supernumerary synapses, have an …

Immunological and toxicological considerations for the design of liposomes

CT Inglut, AJ Sorrin, T Kuruppu, S Vig, J Cicalo… - Nanomaterials, 2020 - mdpi.com
Liposomes hold great potential as gene and drug delivery vehicles due to their
biocompatibility and modular properties, coupled with the major advantage of attenuating …

COVID-19-associated coagulopathy: an exacerbated immunothrombosis response

A Jayarangaiah, PT Kariyanna… - Clinical and Applied …, 2020 - journals.sagepub.com
Since the onset of the global pandemic in early 2020, coronavirus disease 2019 (COVID-19)
has posed a multitude of challenges to health care systems worldwide. In order to combat …

[HTML][HTML] A review on phospholipids and their main applications in drug delivery systems

J Li, X Wang, T Zhang, C Wang, Z Huang, X Luo… - Asian journal of …, 2015 - Elsevier
Phospholipids have the characteristics of excellent biocompatibility and a especial
amphiphilicity. These unique properties make phospholipids most appropriate to be …

[HTML][HTML] The era of thromboinflammation: platelets are dynamic sensors and effector cells during infectious diseases

L Guo, MT Rondina - Frontiers in immunology, 2019 - frontiersin.org
Platelets are anucleate cells produced by megakaryocytes. In recent years, a robust body of
literature supports the evolving role of platelets as key sentinel and effector cells in infectious …

Thrombosis as an intravascular effector of innate immunity

B Engelmann, S Massberg - Nature Reviews Immunology, 2013 - nature.com
Thrombosis is the most frequent cause of mortality worldwide and is closely linked to
haemostasis, which is the biological mechanism that stops bleeding after the injury of blood …

[HTML][HTML] P4-ATPases as phospholipid flippases—structure, function, and enigmas

JP Andersen, AL Vestergaard, SA Mikkelsen… - Frontiers in …, 2016 - frontiersin.org
P4-ATPases comprise a family of P-type ATPases that actively transport or flip phospholipids
across cell membranes. This generates and maintains membrane lipid asymmetry, a …

The use of natural and synthetic phospholipids as pharmaceutical excipients

P Van Hoogevest, A Wendel - European journal of lipid science …, 2014 - Wiley Online Library
In pharmaceutical formulations, phospholipids obtained from plant or animal sources and
synthetic phospholipids are used. Natural phospholipids are purified from, eg, soybeans or …