Immunity to invasive fungal diseases

A Casadevall - Annual review of immunology, 2022 - annualreviews.org
Invasive fungal diseases are rare in individuals with intact immunity. This, together with the
fact that there are only a few species that account for most mycotic diseases, implies a …

Developing novel antifungals: lessons from G protein-coupled receptors

V Velazhahan, BL McCann, E Bignell… - Trends in pharmacological …, 2023 - cell.com
Up to 1.5 million people die yearly from fungal disease, but the repertoire of antifungal drug
classes is minimal and the incidence of drug resistance is rising rapidly. This dilemma was …

Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species

JL Steenwyk, ME Mead, SL Knowles, HA Raja… - Genetics, 2020 - academic.oup.com
Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of
Virulence Across Aspergillus Species | Genetics | Oxford Academic Skip to Main Content …

Aspergillus fumigatus mitogen-activated protein kinase MpkA is involved in gliotoxin production and self-protection

P Alves de Castro, C Figueiredo Pinzan… - Nature …, 2024 - nature.com
Aspergillus fumigatus is a saprophytic fungus that can cause a variety of human diseases
known as aspergillosis. Mycotoxin gliotoxin (GT) production is important for its virulence and …

Process, advances, and perspectives of graphene oxide-SELEX for the development of aptamer molecular probes: A comprehensive review

Z Chen, Y Yang, X Cui, L Chai, H Liu, Y Pan… - Analytica Chimica …, 2024 - Elsevier
Background Aptamers are screened via the systematic evolution of ligands by exponential
enrichment (SELEX) and are widely used in molecular diagnostics and targeted therapies …

Epipolythiodioxopiperazine‐Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

EM Huber - ChemBioChem, 2022 - Wiley Online Library
Epipolythiodioxopiperazines (ETPs) are fungal secondary metabolites that share a 2, 5‐
diketopiperazine scaffold built from two amino acids and bridged by a sulfide moiety …

Gliotoxin, an Immunosuppressive Fungal Metabolite, Primes Plant Immunity: Evidence from Trichoderma virens-Tomato Interaction

R Zaid, R Koren, E Kligun, R Gupta… - MBio, 2022 - Am Soc Microbiol
Beneficial interaction of members of the fungal genus Trichoderma with plant roots primes
the plant immune system, promoting systemic resistance to pathogen infection. Some strains …

Target-Induced AIE Effect Coupled with CRISPR/Cas12a System Dual-Signal Biosensing for the Ultrasensitive Detection of Gliotoxin

X Ma, Y Zhang, X Qiao, Y Yuan, Q Sheng… - Analytical …, 2023 - ACS Publications
Here, a novel rapid and ultrasensitive aptamer biosensor was designed for target-induced
activation of AIE effect and followed by the activation of Crispr Cas12a (LbCpf1)-mediated …

Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters

W Wang, Y Yu, NP Keller, P Wang - International Journal of Molecular …, 2021 - mdpi.com
Fungal secondary metabolites are renowned toxins as well as valuable sources of
antibiotics, cholesterol-lowering drugs, and immunosuppressants; hence, great efforts were …

Diversity of secondary metabolism in Aspergillus nidulans clinical isolates

MT Drott, RW Bastos, A Rokas, LNA Ries, T Gabaldón… - Msphere, 2020 - Am Soc Microbiol
The filamentous fungus Aspergillus nidulans has been a primary workhorse used to
understand fungal genetics. Much of this work has focused on elucidating the genetics of …