The complement system was discovered at the end of the 19th century as a heat-labile
plasma component that “complemented” the antibodies in killing microbes, hence the name …

Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which
requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening …

The renaissance of complement diagnostics and therapeutics has introduced precision
medicine into a widened field of complement-mediated diseases. In particular, complement …

The membrane attack complex—also known as C5b-9—is the end-product of the classical,
lectin, and alternative complement pathways. It is thought to play an important role in the …

IgA nephropathy (IgAN) is the most prevalent primary glomerulonephritis worldwide, with
diverse clinical manifestations characterized by recurrent gross hematuria or microscopic …

Immunoglobulin (Ig) A nephropathy (IgAN) is the commonest form of primary
glomerulonephritis worldwide and is, considered a significant cause of end-stage renal …

IgA nephropathy (IgAN), the most common primary glomerular disease worldwide, is
characterized by glomerular deposition of IgA1-containing immune complexes. The IgA1 …

IgA nephropathy (IgAN) is the most common pattern of primary glomerular disease reported
worldwide. Up to 40% of those with IgAN progress to end‐stage kidney disease within 20 …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world among
patients undergoing renal biopsy. Approximately 30% of patients with IgAN develop end …

Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis
worldwide. Recent years have witnessed significant improvements in the understanding of …