Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …
from target identification to lead discovery and optimization, preclinical validation and …
Nanoparticles of metal‐organic frameworks: on the road to in vivo efficacy in biomedicine
T Simon‐Yarza, A Mielcarek, P Couvreur… - Advanced …, 2018 - Wiley Online Library
In the past few years, numerous studies have demonstrated the great potential of nano
particles of metal‐organic frameworks (nanoMOFs) at the preclinical level for biomedical …
particles of metal‐organic frameworks (nanoMOFs) at the preclinical level for biomedical …
Hydrogel microenvironments for cancer spheroid growth and drug screening
Y Li, E Kumacheva - Science advances, 2018 - science.org
Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …
Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine
Electrospinning provides an enabling nanotechnology platform for generating a rich variety
of novel structured materials in many biomedical applications including drug delivery …
of novel structured materials in many biomedical applications including drug delivery …
Magnetic–acoustic sequentially actuated CAR T cell microrobots for precision navigation and in situ antitumor immunoactivation
Despite its clinical success, chimeric antigen receptor T (CAR T)‐cell immunotherapy
remains limited in solid tumors, owing to the harsh physical barriers and …
remains limited in solid tumors, owing to the harsh physical barriers and …
Electrospun fibrous architectures for drug delivery, tissue engineering and cancer therapy
The versatile electrospinning technique is recognized as an efficient strategy to deliver
active pharmaceutical ingredients and has gained tremendous progress in drug delivery …
active pharmaceutical ingredients and has gained tremendous progress in drug delivery …
Biodegradable polymers for biomedical additive manufacturing
D Puppi, F Chiellini - Applied materials today, 2020 - Elsevier
The tremendous interest received by additive manufacturing (AM) within the biomedical
community is a consequence of the great versatility offered in terms of processing approach …
community is a consequence of the great versatility offered in terms of processing approach …
[HTML][HTML] Self-assemble peptide biomaterials and their biomedical applications
J Chen, X Zou - Bioactive materials, 2019 - Elsevier
Inspired by self-assembling peptides found in native proteins, deliberately designed
engineered peptides have shown outstanding biocompatibility, biodegradability, and …
engineered peptides have shown outstanding biocompatibility, biodegradability, and …
A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers
S Utech, AR Boccaccini - Journal of materials science, 2016 - Springer
There is a growing demand for three-dimensional scaffolds for expanding applications in
regenerative medicine, tissue engineering, and cell culture techniques. The material …
regenerative medicine, tissue engineering, and cell culture techniques. The material …
3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed,
several microdevices are being developed specifically for clinical use to test novel cancer …
several microdevices are being developed specifically for clinical use to test novel cancer …