Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Nanoparticles of metal‐organic frameworks: on the road to in vivo efficacy in biomedicine

T Simon‐Yarza, A Mielcarek, P Couvreur… - Advanced …, 2018 - Wiley Online Library
In the past few years, numerous studies have demonstrated the great potential of nano
particles of metal‐organic frameworks (nanoMOFs) at the preclinical level for biomedical …

Hydrogel microenvironments for cancer spheroid growth and drug screening

Y Li, E Kumacheva - Science advances, 2018 - science.org
Multicellular cancer spheroids (MCSs) have emerged as a promising in vitro model that
replicates many features of solid tumors in vivo. Biomimetic hydrogel scaffolds for MCS …

Electrospinning: An enabling nanotechnology platform for drug delivery and regenerative medicine

S Chen, R Li, X Li, J Xie - Advanced drug delivery reviews, 2018 - Elsevier
Electrospinning provides an enabling nanotechnology platform for generating a rich variety
of novel structured materials in many biomedical applications including drug delivery …

Magnetic–acoustic sequentially actuated CAR T cell microrobots for precision navigation and in situ antitumor immunoactivation

X Tang, Y Yang, M Zheng, T Yin, G Huang… - Advanced …, 2023 - Wiley Online Library
Despite its clinical success, chimeric antigen receptor T (CAR T)‐cell immunotherapy
remains limited in solid tumors, owing to the harsh physical barriers and …

Electrospun fibrous architectures for drug delivery, tissue engineering and cancer therapy

Y Ding, W Li, F Zhang, Z Liu… - Advanced Functional …, 2019 - Wiley Online Library
The versatile electrospinning technique is recognized as an efficient strategy to deliver
active pharmaceutical ingredients and has gained tremendous progress in drug delivery …

Biodegradable polymers for biomedical additive manufacturing

D Puppi, F Chiellini - Applied materials today, 2020 - Elsevier
The tremendous interest received by additive manufacturing (AM) within the biomedical
community is a consequence of the great versatility offered in terms of processing approach …

[HTML][HTML] Self-assemble peptide biomaterials and their biomedical applications

J Chen, X Zou - Bioactive materials, 2019 - Elsevier
Inspired by self-assembling peptides found in native proteins, deliberately designed
engineered peptides have shown outstanding biocompatibility, biodegradability, and …

A review of hydrogel-based composites for biomedical applications: enhancement of hydrogel properties by addition of rigid inorganic fillers

S Utech, AR Boccaccini - Journal of materials science, 2016 - Springer
There is a growing demand for three-dimensional scaffolds for expanding applications in
regenerative medicine, tissue engineering, and cell culture techniques. The material …

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

AR Aref, M Campisi, E Ivanova, A Portell, D Larios… - Lab on a Chip, 2018 - pubs.rsc.org
Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy. Indeed,
several microdevices are being developed specifically for clinical use to test novel cancer …