[HTML][HTML] Overview of the mechanisms of oxidative stress: impact in inflammation of the airway diseases

GD Albano, RP Gagliardo, AM Montalbano, M Profita - Antioxidants, 2022 - mdpi.com
Inflammation of the human lung is mediated in response to different stimuli (eg, physical,
radioactive, infective, pro-allergenic or toxic) such as cigarette smoke and environmental …

Systemic manifestations and comorbidities of COPD

PJ Barnes, BR Celli - European respiratory journal, 2009 - Eur Respiratory Soc
Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …

[HTML][HTML] SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1

S Zhang, J Wang, L Wang, S Aliyari… - Cellular & molecular …, 2022 - nature.com
Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …

Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic …

A Valavanidis, K Fiotakis… - Journal of Environmental …, 2008 - Taylor & Francis
Air pollution has been considered a hazard to human health. In the past decades, many
studies highlighted the role of ambient airborne particulate matter (PM) as an important …

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

D Malhotra, E Portales-Casamar, A Singh… - Nucleic acids …, 2010 - academic.oup.com
The Nrf2 (nuclear factor E2 p45-related factor 2) transcription factor responds to diverse
oxidative and electrophilic environmental stresses by circumventing repression by Keap1 …

Diabetic cardiomyopathy and its mechanisms: role of oxidative stress and damage

Q Liu, S Wang, L Cai - Journal of diabetes investigation, 2014 - Wiley Online Library
Diabetic cardiomyopathy as an important threat to health occurs with or without coexistence
of vascular diseases. The exact mechanisms underlying the disease remain incompletely …

[HTML][HTML] Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury

R Zhao, L Wang, T Wang, P Xian, H Wang… - Journal of Controlled …, 2022 - Elsevier
Mesenchymal stem cell-derived small extracellular vesicles (MSC-EVs) are promising
nanotherapeutic agent for pneumonia (bacterial origin, COVID-19), but the optimal …

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

XJ Wang, Z Sun, NF Villeneuve, S Zhang… - …, 2008 - academic.oup.com
Drug resistance during chemotherapy is the major obstacle to the successful treatment of
many cancers. Here, we report that inhibition of NF-E2-related factor 2 (Nrf2) may be a …

The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles

N Li, T Xia, AE Nel - Free radical biology and medicine, 2008 - Elsevier
Ambient particulate matter (PM) is an environmental factor that has been associated with
increased respiratory morbidity and mortality. The major effect of ambient PM on the …

[HTML][HTML] Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

J Duan, J Cui, Z Yang, C Guo, J Cao, M Xi… - Journal of …, 2019 - Springer
Background Previous studies had showed that Apelin 13 could protect against apoptosis
induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 …