[HTML][HTML] Protective actions of nuclear factor erythroid 2-related factor 2 (NRF2) and downstream pathways against environmental stressors
Environmental risk factors, including noise, air pollution, chemical agents, ultraviolet
radiation (UVR) and mental stress have a considerable impact on human health. Oxidative …
radiation (UVR) and mental stress have a considerable impact on human health. Oxidative …
DJ-1, a cancer-and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2
CM Clements, RS McNally, BJ Conti… - Proceedings of the …, 2006 - National Acad Sciences
DJ-1/PARK7, a cancer-and Parkinson's disease (PD)-associated protein, protects cells from
toxic stresses. However, the functional basis of this protection has remained elusive. We …
toxic stresses. However, the functional basis of this protection has remained elusive. We …
Reactive oxygen species-induced activation of the MAP kinase signaling pathways
JA McCubrey, MM LaHair… - Antioxidants & redox …, 2006 - liebertpub.com
An abundance of scientific literature exists demonstrating that oxidative stress influences the
MAPK signaling pathways. This review summarizes these findings for the ERK, JNK, p38 …
MAPK signaling pathways. This review summarizes these findings for the ERK, JNK, p38 …
[HTML][HTML] MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism
M Cen, W Ouyang, W Zhang, L Yang, X Lin, M Dai… - Redox biology, 2021 - Elsevier
Recently, numerous evidence has revealed that excessive reactive oxygen species (ROS)
production and mitochondrial disruption during acute lung injury (ALI) and its most severe …
production and mitochondrial disruption during acute lung injury (ALI) and its most severe …
The protective role of Nrf2 in streptozotocin-induced diabetic nephropathy
OBJECTIVE Diabetic nephropathy is one of the major causes of renal failure, which is
accompanied by the production of reactive oxygen species (ROS). Nrf2 is the primary …
accompanied by the production of reactive oxygen species (ROS). Nrf2 is the primary …
Nrf2 deficiency induces oxidative stress and promotes RANKL-induced osteoclast differentiation
S Hyeon, H Lee, Y Yang, W Jeong - Free Radical Biology and Medicine, 2013 - Elsevier
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor that
regulates the expression of a variety of antioxidant and detoxification genes through an …
regulates the expression of a variety of antioxidant and detoxification genes through an …
Gestational hypoxia and developmental plasticity
Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …
The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis
The disruption of the NRF2 (nuclear factor erythroid-derived 2-like 2)/glutathione-mediated
antioxidant defense pathway is a critical step in the pathogenesis of several chronic …
antioxidant defense pathway is a critical step in the pathogenesis of several chronic …
[HTML][HTML] Redox mechanisms in hepatic chronic wound healing and fibrogenesis
E Novo, M Parola - Fibrogenesis & tissue repair, 2008 - Springer
Reactive oxygen species (ROS) generated within cells or, more generally, in a tissue
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …
environment, may easily turn into a source of cell and tissue injury. Aerobic organisms have …
[HTML][HTML] Mechanosensing and mechanoregulation of endothelial cell functions
Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …
elements regulated by dynamic interactions between cytoskeletal elements and cell …