Progress in understanding the genetics of calcium-containing nephrolithiasis

JA Sayer - Journal of the American Society of Nephrology, 2017 - journals.lww.com
Renal stone disease is a frequent condition, causing a huge burden on health care systems
globally. Calcium-based calculi account for around 75% of renal stone disease and the …

The fruit fly kidney stone models and their application in drug development

S Wang, Y Ju, L Gao, Y Miao, H Qiao, Y Wang - Heliyon, 2022 - cell.com
Kidney stone disease is a global problem affecting about 12% of the world population. Novel
treatments to control this disease have a huge demand. Here we argue that the fruit fly, as …

Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis

Y Liu, Y Zhao, Y Shukha, H Lu, L Wang, Z Liu, C Liu… - Cell reports, 2021 - cell.com
Dysregulated glycine metabolism is emerging as a common denominator in cardiometabolic
diseases, but its contribution to atherosclerosis remains unclear. In this study, we …

Dietary vinegar prevents kidney stone recurrence via epigenetic regulations

W Zhu, Y Liu, Y Lan, X Li, L Luo, X Duan, M Lei… - …, 2019 - thelancet.com
Background Epidemiological evidence of over 9000 people suggests that daily intake of
vinegar whose principal bioactive component is acetic acid is associated with a reduced risk …

Loss of MeCP2 causes urological dysfunction and contributes to death by kidney failure in mouse models of Rett syndrome

CS Ward, TW Huang, JA Herrera, RC Samaco… - PLoS …, 2016 - journals.plos.org
Rett Syndrome (RTT) is a neurodevelopmental disorder characterized by loss of acquired
skills during development, autonomic dysfunction, and an increased risk for premature …

Kidney stone formation in a novel murine model of polycystic kidney disease

HAL Riddle, S Zhang, F Qian… - American Journal …, 2022 - journals.physiology.org
Individuals with autosomal dominant polycystic kidney disease have a higher incidence of
stone formation than the general population. However, there are no cystic animal models …

[PDF][PDF] Preclinical assessment of antiurolithiatic activity of Mangifera indica seeds on ethylene glycol induced urolithiasis rat model

S Iman, U Saleem, B Ahmad - Pak Vet J, 2020 - pvj.com.pk
Urolithiasis is recognized as the 3rd most common condition of urinary tract, which may
aggravate some disorders, such as urinary tract infections and prostate complaints (Goyal et …

Amelioration of lithiatic injury to renal tissue by candesartan and sodium thiosulfate in a rat model of nephrolithiasis

NE El-Ashmawy, HA El-Bahrawy, HH Ashmawy… - Plos one, 2021 - journals.plos.org
Aim Nephrolithiasis is a chronic metabolic condition affecting 10% of population worldwide.
The present study aimed to investigate the possible protective role of candesartan (CAND) …

High doses of boron have no protective effect against nephrolithiasis or oxidative stress in a rat model

AB Ergul, M Kara, C Karakukcu, A Tasdemir… - Biological trace element …, 2018 - Springer
Boron plays roles in the metabolism of calcium, vitamin D, steroid hormones, healthy bone
development, and maintenance of cell membranes. The biological effects of boron are dose …

Anti-Urolithiatic Activity of the Ethanolic Extract of Cassia auriculata against Ethylene Glycol Induced Urolithiasis in Experimental Rats

C Sumanjali, M Shashidhar, M Sravani… - Research Journal of …, 2021 - indianjournals.com
The objective was to investigate the anti-urolithiatic effect of ethanolic extract of Cassia
auriculate on ethylene glycol (EG) induced urolithiasis in experimental rats. The animals …