Aims Increased chemosensitivity to carbon dioxide (CO2) is an important trigger of central
apnoeas (CA) in heart failure (HF), with negative impact on outcome. We hypothesized that …

Background: Dilated cardiomyopathy (DCM) is a life-threatening disease, resulting in
refractory heart failure. An immune disorder underlies the pathophysiology associated with …

Cardiomyopathy is a disease of myocardium categorized into three major forms,
hypertrophic (HCM), dilated (DCM) and restrictive cardiomyopathy (RCM), which has …

Oestradiol (E2) is known as a female reproductive hormone with pleiotropic effects on the
cardiovascular system. Local E2 biosynthesis such as in the brain and myocardial cells have …

Although ghrelin has been demonstrated to improve cardiac function in heart failure, its
therapeutic efficacy on the life expectancy remains unknown. We aim to examine whether …

Background and Purpose The Ca2+ sensitizer pimobendan is a unique inotropic agent that
improves cardiac contractility with less of an increase in oxygen consumption and potentially …

Glycogen synthase kinase-3β (GSK-3β) plays a central role in both cardiac physiology and
pathology. Herein we want to clarify the role of GSK-3β in familial dilated cardiomyopathy …

Aim Monoamine oxidases (MAOs) are mitochondrial enzymes, with 2 isoforms, A and B that
convert biogenic amines to their corresponding aldehydes via a reaction that produces …

The aim of this study was to evaluate cardiac vagal nerve activity and identify the
abnormality of cardiac vagal control in heart failure caused by dilated cardiomyopathy …

Antecedentes: Los cardiomiocitos sintetizan, utilizan y recapturan serotonina, la cual
participa en la modulación parácrina y autócrina de la actividad del corazón y en la …