The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - ASPET
Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …
a binding site with unknown function to a firmly established major effector within the …
[HTML][HTML] Brain renin–angiotensin system at the intersect of physical and cognitive frailty
C Cosarderelioglu, LS Nidadavolu… - Frontiers in …, 2020 - frontiersin.org
The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …
system regulating water and electrolyte balance, systemic vascular resistance, blood …
[HTML][HTML] Diagnosing sarcopenia: Functional perspectives and a new algorithm from ISarcoPRM
Sarcopenia is an important public health problem, characterized by age-related loss of
muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and …
muscle mass and muscle function. It is a precursor of physical frailty, mobility limitation, and …
[HTML][HTML] Neurovascular unit dysfunction and blood–brain barrier hyperpermeability contribute to schizophrenia neurobiology: a theoretical integration of clinical and …
S Najjar, S Pahlajani, V De Sanctis, JNH Stern… - Frontiers in …, 2017 - frontiersin.org
Schizophrenia is a psychotic disorder characterized by delusions, hallucinations, negative
symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically …
symptoms, as well as behavioral and cognitive dysfunction. It is a pathoetiologically …
Neuroprotective effects of angiotensin receptor blockers
S Villapol, JM Saavedra - American journal of hypertension, 2015 - academic.oup.com
Angiotensin II receptor blockers (ARBs, collectively called sartans) are widely used
compounds therapeutically effective in cardiovascular disorders, renal disease, the …
compounds therapeutically effective in cardiovascular disorders, renal disease, the …
[HTML][HTML] Cholinergic dysfunction in COVID-19: frantic search and hoping for the best
A novel coronavirus known as severe acute respiratory syndrome coronavirus type 2 (SARS-
CoV-2) is a potential cause of acute respiratory infection called coronavirus disease 2019 …
CoV-2) is a potential cause of acute respiratory infection called coronavirus disease 2019 …
[HTML][HTML] Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future
F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …
Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer′ s disease?
D Luque-Contreras, K Carvajal… - Oxidative medicine …, 2014 - Wiley Online Library
Alzheimer's disease (AD) is a major neurodegenerative disease affecting the elderly.
Clinically, it is characterized by a progressive loss of memory and cognitive function …
Clinically, it is characterized by a progressive loss of memory and cognitive function …
[HTML][HTML] Targeting renin–angiotensin system against Alzheimer's disease
Renin Angiotensin System (RAS) is a hormonal system that regulates blood pressure and
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …
fluid balance through a coordinated action of renal, cardiovascular, and central nervous …
Review of the anti-inflammatory effect of SIRT1 and SIRT2 modulators on neurodegenerative diseases
Y Zhang, S Anoopkumar-Dukie, D Arora… - European journal of …, 2020 - Elsevier
Neurodegenerative disease refers to a range of chronic and progressive disorders that are
characterized by dysfunction and loss of neurons. Neurodegeneration involves protein …
characterized by dysfunction and loss of neurons. Neurodegeneration involves protein …