Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

T Fu, LJ Dai, SY Wu, Y Xiao, D Ma, YZ Jiang… - Journal of hematology & …, 2021 - Springer
Tumors are not only aggregates of malignant cells but also well-organized complex
ecosystems. The immunological components within tumors, termed the tumor immune …

Volatile compounds in human breath: critical review and meta-analysis

T Issitt, L Wiggins, M Veysey, ST Sweeney… - Journal of Breath …, 2022 - iopscience.iop.org
Volatile compounds contained in human breath reflect the inner workings of the body. A
large number of studies have been published that link individual components of breath to …

Sodium and its manifold impact on our immune system

K Jobin, DN Müller, J Jantsch, C Kurts - Trends in immunology, 2021 - cell.com
The Western diet is rich in salt, and a high salt diet (HSD) is suspected to be a risk factor for
cardiovascular diseases. It is now widely accepted that an experimental HSD can stimulate …

In vivo evidence for voltage-gated sodium channel expression in carcinomas and potentiation of metastasis

MBA Djamgoz, SP Fraser, WJ Brackenbury - Cancers, 2019 - mdpi.com
A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …

The modulatory effect of high salt on immune cells and related diseases

X Li, A Alu, Y Wei, X Wei, M Luo - Cell proliferation, 2022 - Wiley Online Library
Background The adverse effect of excessive salt intake has been recognized in decades.
Researchers have mainly focused on the association between salt intake and hypertension …

Anti-Tumor Activity of Hypericum perforatum L. and Hyperforin through Modulation of Inflammatory Signaling, ROS Generation and Proton Dynamics

M Menegazzi, P Masiello, M Novelli - Antioxidants, 2020 - mdpi.com
In this paper we review the mechanisms of the antitumor effects of Hypericum perforatum
L.(St. John's wort, SJW) and its main active component hyperforin (HPF). SJW extract is …

Targeting ion channels for cancer treatment: current progress and future challenges

AL Capatina, D Lagos, WJ Brackenbury - Targets of Cancer Diagnosis and …, 2020 - Springer
Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety
of processes such as maintenance of cellular osmolarity and membrane potential, motility …

Programmable DNAzyme Computing for Specific In Vivo Imaging: Intracellular Stimulus-Unlocked Target Sensing and Signal Amplification

Y Wu, Z Li, M Shi, K Yuan, HM Meng, L Qu… - Analytical …, 2021 - ACS Publications
Molecular probe that enables in vivo imaging is the cornerstone of accurate disease
diagnosis, prognostic estimation, and therapies. Although several nucleic acid-based …

Sodium channels and the ionic microenvironment of breast tumours

TK Leslie, WJ Brackenbury - The Journal of Physiology, 2023 - Wiley Online Library
Cancers of epithelial origin such as breast, prostate, cervical, gastric, colon and lung cancer
account for a large proportion of deaths worldwide. Better treatment of metastasis, the main …

Quantitative elemental mapping of biological tissues by laser-induced breakdown spectroscopy using matrix recognition

P Janovszky, A Kéri, DJ Palásti, L Brunnbauer… - Scientific Reports, 2023 - nature.com
The present study demonstrates the importance of converting signal intensity maps of
organic tissues collected by laser-induced breakdown spectroscopy (LIBS) to elemental …