Objectives Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na+)
channels (VGSCs), and preclinical studies show that these medications reduce tumour …

Spatial and temporal control of calcium (Ca 2+) levels is essential for the background
rhythms and responses of living cells to environmental stimuli. Whatever other regulators a …

A plethora of ion channels have been shown to be involved systemically in the
pathophysiology of cancer and ion channel blockers can produce anti-metastatic effects …

High salt (NaCl) concentrations are found in a number of tissues under physiological and
pathological conditions. Here, we analyzed the effects induced by high salt on the function of …

The task of detecting common and unique characteristics among different cancer subtypes is
an important focus of research that aims to improve personalized therapies. Unlike current …

The development of therapies that can suppress invasion and prevent metastasis,'anti-
metastatic drugs', is an important area of unmet therapeutic need. The new results of a …

The purpose of this work was to develop a novel method to disentangle the intra-and
extracellular components of the total sodium concentration (TSC) in breast cancer from a …

A high-salt diet significantly impacts various diseases, ilncluding cancer and immune
diseases. Recent studies suggest that the high-salt/hyperosmotic environment in the body …

Despite extensive basic and clinical research on immune checkpoint regulatory pathways,
little is known about the effects of the ionic tumor microenvironment on immune checkpoint …

Na+ plays a vital role in numerous physiological processes across humans and animals,
necessitating a comprehensive understanding of Na+ transmembrane transport. Among the …