For more than a century, hydrogen sulfide (H2S) has been regarded as a toxic gas. This
review surveys the growing recognition of the role of H2S as an endogenous signaling …

The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric
oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which …

L-type Ca2+ channels play a critical role in regulating Ca2+-dependent signaling in cardiac
myocytes, including excitation-contraction coupling; however, the subcellular localization of …

Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling
intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic …

Reactive nitrogen species (RNS) are various nitric oxide–derived compounds, including
nitroxyl anion, nitrosonium cation, higher oxides of nitrogen, S-nitrosothiols, and dinitrosyl …

Patients with chronic kidney disease have an increased cardiovascular morbidity and
mortality. It has been recognized that the traditional cardiovascular risk factors could only …

Background—Whether left ventricular hypertrophy (LVH) in obesity results from increased
hemodynamic load or altered neurohormonal signaling remains controversial …

Dystrophin is a 427 kDa sub-membrane cytoskeletal protein, associated with the inner
surface membrane and incorporated in a large macromolecular complex of proteins, the …

Mice with a malignant hyperthermia mutation (Y522S) in the ryanodine receptor (RyR1)
display muscle contractures, rhabdomyolysis, and death in response to elevated …

Nitroxyl anion (HNO/NO−), the one-electron reduced form of nitric oxide (NO), induces
positive cardiac inotropy and selective venodilation in the normal in vivo circulation. Here we …