The effects of nitric oxide in biological systems depend on its steady-state concentration and
where it is being produced. The organ where nitric oxide is produced is relevant, and within …

Nitric oxide (NO) is a gaseous molecule that plays many key roles in the cardiovascular
system. Each of the enzymes that generate NO—neuronal, inducible and endothelial NO …

This review describes and summarizes the role of neuronal nitric oxide synthase (nNOS) on
the central nervous system, particularly on brain regions such as the ventrolateral medulla …

Mutations in 11 genes that encode ion channels or their associated proteins cause inherited
long QT syndrome (LQTS) and account for≈ 75–80% of cases (LQT1–11). Direct …

There is growing evidence that the altered production and/or spatiotemporal distribution of
reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the …

▪ Abstract Communication between endothelial cells and cardiomyocytes regulates not only
early cardiac development but also adult cardiomyocyte function, including the contractile …

Nitric oxide (NO) is a short-life molecule produced by the enzyme known as the nitric oxide
synthase (NOS), in a reaction that converts arginine and oxygen into citrulline and NO …

Nitric oxide (NO) is a potent cell-signaling, effector, and vasodilator molecule that plays
important roles in diverse biological effects in the kidney, vasculature, and many other …

The conjugation of arginine to proteins is a part of the N-end rule pathway of protein
degradation. Three amino (N)-terminal residues—aspartate, glutamate and cysteine—are …

Mechanisms underlying gender differences in cardiovascular disease are poorly
understood. We found previously that, under hypercontractile conditions, female hearts …