The SNO-proteome: causation and classifications

D Seth, JS Stamler - Current opinion in chemical biology, 2011 - Elsevier
Cell signaling is a complex and highly regulated process. Post-translational modifications of
proteins serve to sense and transduce cellular signals in a precisely coordinated manner. It …

Caveolae and caveolins in the cardiovascular system

JP Gratton, P Bernatchez, WC Sessa - Circulation research, 2004 - Am Heart Assoc
Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many
cellular processes, including transcytosis of macromolecules, cholesterol transport, and …

Blocking NO synthesis: how, where and why?

P Vallance, J Leiper - Nature Reviews Drug Discovery, 2002 - nature.com
Nitric oxide (NO) is a key physiological mediator, and the association of disordered NO
generation with many pathological conditions has led to much interest in pharmacologically …

Regulation of gene expression by cyclic GMP

RB Pilz, DE Casteel - Circulation research, 2003 - Am Heart Assoc
Cyclic GMP, produced in response to nitric oxide and natriuretic peptides, is a key regulator
of vascular smooth muscle cell contractility, growth, and differentiation, and is implicated in …

Apoptosis and autophagy: decoding calcium signals that mediate life or death

MW Harr, CW Distelhorst - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
Calcium is a versatile and dynamic 2nd messenger that is essential for the survival of all
higher organisms. In cells that undergo activation or excitation, calcium is released from the …

Nitric oxide synthases in heart failure

R Carnicer, MJ Crabtree, V Sivakumaran… - Antioxidants & redox …, 2013 - liebertpub.com
Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Release of hepatocyte growth factor from mechanically stretched skeletal muscle satellite cells and role of pH and nitric oxide

R Tatsumi, A Hattori, Y Ikeuchi… - Molecular biology of …, 2002 - Am Soc Cell Biol
Application of mechanical stretch to cultured adult rat muscle satellite cells results in release
of hepatocyte growth factor (HGF) and accelerated entry into the cell cycle. Stretch activation …

[HTML][HTML] Beetroot, a remarkable vegetable: Its nitrate and phytochemical contents can be adjusted in novel formulations to benefit health and support cardiovascular …

D dos S. Baião, DVT da Silva, VMF Paschoalin - Antioxidants, 2020 - mdpi.com
The cardioprotective effects of dietary nitrate from beetroot in healthy and hypertensive
individuals are undeniable and irrefutable. Nitrate and nitrate-derived nitrite are precursors …

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

J Fauconnier, J Thireau, S Reiken… - Proceedings of the …, 2010 - National Acad Sciences
Patients with Duchenne muscular dystrophy (DMD) have a progressive dilated
cardiomyopathy associated with fatal cardiac arrhythmias. Electrical and functional …

[HTML][HTML] Rethinking endothelial dysfunction as a crucial target in fighting heart failure

C Premer, AJ Kanelidis, JM Hare… - Mayo Clinic Proceedings …, 2019 - Elsevier
Endothelial dysfunction is characterized by nitric oxide dysregulation and an altered redox
state. Oxidative stress and inflammatory markers prevail, thus promoting atherogenesis and …