Cell signaling is a complex and highly regulated process. Post-translational modifications of
proteins serve to sense and transduce cellular signals in a precisely coordinated manner. It …

Caveolae and the caveolae coat proteins, caveolins, are putatively implicated in many
cellular processes, including transcytosis of macromolecules, cholesterol transport, and …

Nitric oxide (NO) is a key physiological mediator, and the association of disordered NO
generation with many pathological conditions has led to much interest in pharmacologically …

Cyclic GMP, produced in response to nitric oxide and natriuretic peptides, is a key regulator
of vascular smooth muscle cell contractility, growth, and differentiation, and is implicated in …

Calcium is a versatile and dynamic 2nd messenger that is essential for the survival of all
higher organisms. In cells that undergo activation or excitation, calcium is released from the …

Significance: The regulation of myocardial function by constitutive nitric oxide synthases
(NOS) is important for the maintenance of myocardial Ca2+ homeostasis, relaxation and …

Application of mechanical stretch to cultured adult rat muscle satellite cells results in release
of hepatocyte growth factor (HGF) and accelerated entry into the cell cycle. Stretch activation …

The cardioprotective effects of dietary nitrate from beetroot in healthy and hypertensive
individuals are undeniable and irrefutable. Nitrate and nitrate-derived nitrite are precursors …

Patients with Duchenne muscular dystrophy (DMD) have a progressive dilated
cardiomyopathy associated with fatal cardiac arrhythmias. Electrical and functional …

Endothelial dysfunction is characterized by nitric oxide dysregulation and an altered redox
state. Oxidative stress and inflammatory markers prevail, thus promoting atherogenesis and …