Anticoagulant agents are widely used in the treatment of thromboembolic events and in
stroke prevention. Data about their effects on bone tissue are in some cases limited or …

Most of the prescribing and dispensing of medicines happens in primary care.
Pharmacogenomics (PGx) is the study and clinical application of the role of genetic variation …

This study aimed to analyze associations between genetic variants and the occurrence of
clinical outcomes in dabigatran, apixaban, and rivaroxaban users. This was a retrospective …

Spontaneous venous thrombosis is often the first clinical sign of cancer, and it is linked to a
worsened survival rate. Traditionally, tumor-cell induced platelet activation has been the …

Natural anticoagulant drugs can be obtained from plants, rich in secondary bioactive
metabolites which, in addition to being effective antioxidants, also possess anticoagulant …

Purpose Although direct oral anticoagulants (DOACs) are associated with an overall
favourable safety profile, the risk of gastrointestinal bleeding with DOACs compared with …

Aims The objectives of this study were to investigate the safety, tolerability, pharmacokinetics
and pharmacodynamics of single and multiple oral doses of ONO‐7684, a novel activated …

Direct oral anticoagulants (DOACs) are a newer class of anticoagulants that inhibit factor Xa
or factor IIa and include drugs such as rivaroxaban, apixaban, edoxaban, betrixaban, and …

Rivaroxaban (RVX), an oral direct factor Xa inhibitor, is being explored as an alternative to
traditional anticoagulans. However, RVX still faces pharmacokinetic limitations and adverse …

Fibrosis, also known as organ scarring, describes a pathological stiffening of organs or
tissues caused by increased synthesis of extracellular matrix (ECM) components. In the past …