Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Parkinson's disease (PD) is clinically, pathologically, and genetically heterogeneous,
resisting distillation to a single, cohesive disorder. Instead, each affected individual develops …

Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

SYNOPSIS (1 paragraph): Parkinson's disease (PD) is a complex age-related
neurodegenerative disease associated with dopamine deficiency and both motor and …

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by
degeneration of the substantia nigra pars compacta and by accumulation of α-synuclein in …

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular
membranes. It aggregates and is genetically linked to Parkinson's disease (PD). Here, we …

Emodin is an anthraquinone derivative found in the roots and bark of a variety of plants,
molds, and lichens. Emodin has been used as a traditional medication for more than 2000 …

Parkinson's disease (PD), the second most common neurodegenerative disease, is
characterised by the motor symptoms of bradykinesia, rigidity and resting tremor and non …

The aggregation and prion-like propagation of α-synuclein are involved in the pathogenesis
of Parkinson's disease. However, the underlying mechanisms regulating the assembly and …