Macrophages can be affected by a variety of factors to change their phenotype and thus
affect their function. Activated macrophages are usually divided into two categories, M1-like …

As angiogenesis is essential for tumor growth and metastasis, controlling tumor-associated
angiogenesis is a promising tactic in limiting cancer progression. The tumor …

Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all
vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 …

Checkpoint blockade immunotherapy established a new paradigm in cancer treatment: for
certain patients curative treatment requires immune reinvigoration. Despite this monumental …

The invention of silica-based bioactive glass in the late 1960s has sparked significant
interest in exploring a wide range of silicon-containing biomaterials from the macroscale to …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

By taking advantage of the excessively upregulated expression of neuropilin (NRP) on the
surface of both glioma cells and endothelial cells of angiogenic blood vessels, the ligand of …

Vascular endothelial growth factor A (VEGF-A) is well known for its key roles in blood vessel
growth. Although most studies on VEGF and VEGF receptors have been focused on their …

In this study, we successfully developed novel tumor homing-penetrating peptide-
functionalized drug-loaded phase-transformation nanoparticles (tLyP-1-10-HCPT-PFP NPs) …

To explore the mechanisms through which hypoxic tumor microenvironment (TME)
modulates the transition of tumor‐associated macrophages (TAMs). The migration ability of …