The isoflavone genistein (la) 1 and the flavone quercetin (2) 2 are competitive inhibitors at
the ATP-binding site of kinases, and synthetic flavones modeled on quercetin have been …

Here we report the expression of major pyrimidine metabolising enzymes in pancreatic
cancer cell lines, chronic pancreatitis tissue and human pancreatic cancer and the in vitro …

The expression of thymidine kinase—an enzyme of the DNA precursor pathway—is strictly
regulated during the normal cellular cycle, but is much higher and permanently expressed in …

We determined the cell cycle-dependent fluctuation of mRNAs that encode different
enzymes of the deoxynucleotide metabolism in permanent cell lines of human and murine …

Fetal cells occur in maternal blood in a substantial proportion of normal pregnancies.
Several different approaches have been used to detect and enrich these cells for non …

It has been demonstrated that protein expression of p16, the inhibitor of cyclin-dependent
kinase 4 and 6, increases 4 fold at the G1/S transition when serum-arrested cells are …

Using a cytofluorometric assay, we studied the time course of thymidine kinase activity
during the cell-cycle in logarithmically growing cells. Two different patterns were found …

This invention provides methods for using novel substituted pyrimidine compounds,
derivatives and analogs thereof to treat diseases such as cancer. Examples of compounds …

Using a combination of centrifugal elutriation and recultivation of synchronised cell
populations we could show that murine thymidine kinase (TK) is rapidly degraded during …

The expression of thymidine kinase--an enzyme of the DNA precursor pathway--is strictly
regulated during the normal cellular cycle, but is much higher and permanently expressed in …