For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …

Alcohol-induced oxidative stress is linked to the metabolism of ethanol involving both
microsomal and mitochondrial systems. Ethanol metabolism is directly involved in the …

Acute and chronic ethanol treatment has been shown to increase the production of reactive
oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many …

Mitochondria are intimately involved in the generation of and defense against reactive
oxygen species (ROS). Mitochondria are themselves targets of oxidative stress and also …

Fatty liver disease associated with chronic alcohol consumption or obesity/type 2 diabetes
has emerged as a serious public health problem. Steatosis, accumulation of triglyceride in …

Liver damage ranges from acute hepatitis to hepatocellular carcinoma, through apoptosis,
necrosis, inflammation, immune response, fibrosis, ischemia, altered gene expression and …

Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …

Fatty livers of obese fa/fa rats are vulnerable to injury when challenged by insults such as
endotoxin, ischemia‐reperfusion or acute ethanol treatment. The objective of this study was …

The importance of oxidative stress in the development of alcoholic liver disease has long
been appreciated. The mechanism by which ethanol triggers an increase in reactive oxygen …