The metalloproteinase (MP) family of zinc-dependent proteases, including matrix
metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin …

Renal fibrosis is the final pathological process common to any ongoing, chronic kidney
injury or maladaptive repair. It is considered as the underlying pathological process of …

Matrix metalloproteinases (MMPs) are endopeptidases within the metzincin protein family
that not only cleave extracellular matrix (ECM) components, but also process the non-ECM …

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer in adults.
When ccRCC is localized to the kidney, surgical resection or ablation of the tumor is often …

BACKGROUND. The molecular understanding of the progression from acute to chronic
organ injury is limited. Ischemia/reperfusion injury (IRI) triggered during kidney …

Renal fibrosis is a failed wound-healing process of the kidney tissue after chronic, sustained
injury, which is a common pathway and pathological marker of virtually every type of chronic …

Introduction The current therapeutic armamentarium to prevent chronic kidney disease
(CKD) progression is limited to the control of blood pressure and in diabetic patients, the …

Objectives: Matrix metallopeptidase-7 (MMP-7) and osteopontin (OPN) are important
components in the pathophysiology of fibrosis in biliary atresia (BA). There has been much …

Chronic kidney disease (CKD) is characterized by the loss of kidney function. The molecular
mechanisms underlying the development and progression of CKD are still not fully …

Biliary atresia (BA) is a rare cholangiopathy of infancy in which the bile ducts obliterate,
leading to profound cholestasis and liver fibrosis. BA is hypothesized to be caused by a viral …