BACKGROUND Matrix metalloproteinases (MMPs) participate in the degradation of
extracellular matrix compounds, maintaining the homeostasis between fibrogenesis and …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with an unmet need
of biomarkers that can aid in the diagnostic and prognostic assessment of the disease and …

ABSTRACT Matrix metalloproteinase 7 (MMP-7) is a secreted endopeptidase involved in the
degradation of extracellular matrix components and the activation of cytokines and growth …

The kidney epithelium, with its intricate arrangement of highly specialized cell types,
constitutes the functional core of the organ. Loss of kidney epithelium is linked to the loss of …

目的连续观察急性马兜铃酸Ⅰ (AAⅠ) 中毒小鼠肾损伤的病理改变和Wnt 通路相关蛋白的表达,
探讨Wnt7b 信号通路参与马兜铃酸肾病(AAN) 损伤修复的机制. 方法观察小鼠暴露于AAⅠ …

High-incidence regions of leptospirosis caused by Leptospira spp. coincide with chronic
kidney disease. This study investigated whether asymptomatic leptospirosis is an emerging …

Fibrosis is a severe complication of many acute and chronic kidney pathologies. According
to current concepts, an imbalance in the synthesis and degradation of the extracellular …

Matrix metalloproteinases (MMPs) are members of calcium dependent-zinc containing
endopeptidases that play a pivotal role in extracellular matrix (ECM) remodeling. MMPs are …

Inflammation and its timely resolution play a critical role in effective host defence and wound
healing. Unresolved inflammatory responses underlie the pathology of many prevalent …

Matrix metalloproteinase-7 (MMP-7) has been shown to play an important role in
pathophysiological processes such as cancer and fibrosis. We previously discovered …